2-[(Trimethylsilyl)oxy]-1,3,2-dioxaphospholane

Base Information

• Chemical Name: 2-[(Trimethylsilyl)oxy]-1,3,2-dioxaphospholane
• CAS No.: 58068-62-5
• Molecular Formula: C5H13O3PSi
• Molecular Weight: 180.214181
• DSSTox Substance ID: DTXSID80554435
• Wikidata: Q82435423
• Mol file: 58068-62-5.mol

Synonyms:2-[(Trimethylsilyl)oxy]-1,3,2-dioxaphospholane;58068-62-5;DTXSID80554435;AKOS006284166

Chemical Property of 2-[(Trimethylsilyl)oxy]-1,3,2-dioxaphospholane

Chemical Property:

• PSA: 41.28000
• LogP: 2.11160
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 180.03715780
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)OP1OCCO1

Technology Process of 2-[(Trimethylsilyl)oxy]-1,3,2-dioxaphospholane

There total 4 articles about 2-[(Trimethylsilyl)oxy]-1,3,2-dioxaphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Trimethylsilanol (1066-40-6) + 2-chloro-1,3,2-dioxaphospholan (822-39-9) → 2-trimethylsiloxy-1,3,2-dioxaphospholan (58068-62-5)

Guidance literature:

Trimethylsilanol; In dichloromethane; at 20 ℃; for 0.5h;

2-chloro-1,3,2-dioxaphospholan; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

2-chloro-1,3,2-dioxaphospholan (822-39-9) + N-Trimethylsilylacetamide (13435-12-6) → 2-trimethylsiloxy-1,3,2-dioxaphospholan (58068-62-5)

Guidance literature:

With triethylamine; In benzene;

Reference yield:

2-chloro-1,3,2-dioxaphospholan (822-39-9) + N,N-bis(trimethylsilyl)acetamide (10416-58-7) → 2-trimethylsiloxy-1,3,2-dioxaphospholan (58068-62-5)

Guidance literature:

at 120 - 160 ℃;

DOI:10.1007/BF01179480

upstream raw materials:

Trimethylsilanol

2-chloro-1,3,2-dioxaphospholan

N-Trimethylsilylacetamide

N,N-bis(trimethylsilyl)acetamide