N-(Trimethylsilyl)acetamide

Base Information Edit

Chemical Name:N-(Trimethylsilyl)acetamide
CAS No.:13435-12-6
Molecular Formula:C5H13 N O Si
Molecular Weight:131.25
Hs Code.:29319090
European Community (EC) Number:236-565-7
NSC Number:139859
DSSTox Substance ID:DTXSID8065454
Nikkaji Number:J55.333F
Wikidata:Q72514424
Mol file:13435-12-6.mol

Synonyms:N-(Trimethylsilyl)acetamide;13435-12-6;N-Trimethylsilylacetamide;Trimethylsilylacetamide;ACETAMIDE, N-(TRIMETHYLSILYL)-;(Acetylamino)trimethylsilane;Acetamide, TMS derivative;trimethylsilyl acetamide;C5H13NOSi;n-trimethylsilyl-acetamide;EINECS 236-565-7;NSC 139859;BRN 0741928;n-(trimethylsilyl)-acetamide;4-04-00-04011 (Beilstein Handbook Reference);N-TMS-acetamide;Acetamide, N -(trimethylsilyl)-;N-trimethylsilylacetoamide;n-trimethylsilyl acetamide;SCHEMBL321022;C5-H13-N-O-Si;N-mono(trimethylsilyl)acetamide;DTXSID8065454;SCHEMBL15719959;N-(Trimethylsilyl)acetamide, 95%;AMY42260;WLN: 1VM-SI-1&1&1;CT3250;MFCD00008671;NSC139859;AKOS015837704;FS-5493;NSC-139859;CS-0187550;FT-0654581;T0590;D92366;EN300-109884;S18875;A806768;J-006522;N-(Trimethylsilyl)acetamide, for GC derivatization, >=98.0% (GC)

Suppliers and Price of N-(Trimethylsilyl)acetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Trimethylsilyl
10g
$ 319.00

TRC
N-Trimethylsilylacetamide
25g
$ 60.00

TCI Chemical
N-Trimethylsilylacetamide >98.0%(GC)
25g
$ 118.00

Sigma-Aldrich
N-(Trimethylsilyl)acetamide for GC derivatization, ≥98.0% (GC)
1g
$ 31.90

Sigma-Aldrich
N-(Trimethylsilyl)acetamide 95%
25g
$ 68.90

Sigma-Aldrich
N-(Trimethylsilyl)acetamide for GC derivatization, ≥98.0% (GC)
5g
$ 67.50

Medical Isotopes, Inc.
N-Trimethylsilylacetamide
500 g
$ 2120.00

Medical Isotopes, Inc.
N-Trimethylsilylacetamide
50 g
$ 640.00

Crysdot
N-(Trimethylsilyl)acetamide 95+%
1000g
$ 432.00

Chemenu
N-Trimethylsilylacetamide 95%
1000g
$ 404.00

Total 51 raw suppliers

Chemical Property of N-(Trimethylsilyl)acetamide Edit

Chemical Property:

Appearance/Colour:WHITE TO YELLOWISH CRYSTALLINE MASS
Vapor Pressure:0.298mmHg at 25°C
Melting Point:46-49 °C(lit.)
Refractive Index:1.421
Boiling Point:84ºC 18 mm Hg(lit.),190.2 °C at 760 mmHg
PKA:18.23±0.46(Predicted)
Flash Point:70 ºC
PSA：29.10000
Density:0.859 g/cm³
LogP:1.34830
Storage Temp.:Flammables area
Sensitive.:Moisture Sensitive
Solubility.:Chloroform, DMSO, Methanol
Water Solubility.:reacts
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:131.076640573
Heavy Atom Count:8
Complexity:95.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trimethylsilyl ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi-F,Xi,F
Statements: 36/37/38-11
Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=O)N[Si](C)(C)C
Uses N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

Technology Process of N-(Trimethylsilyl)acetamide

There total 38 articles about N-(Trimethylsilyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 75-36-5
acetyl chloride

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 13435-12-6
N-Trimethylsilylacetamide

Guidance literature:: In hexane; for 2h; Heating;
DOI:10.1021/jo00170a050

Reference yield: 87.0%

: 563-80-4
3-methyl-butan-2-one

: 10416-59-8
N,O-bis-(trimethylsilyl)-acetamide

: 17510-45-1
2-(trimethylsilyloxy)-3-methyl-1-butene

: 13435-12-6
N-Trimethylsilylacetamide

Guidance literature:: With sodium; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 0.05h; Ambient temperature;
DOI:10.1016/S0022-328X(00)85896-9