1-CHLORO-6-PHENYLHEXANE

Base Information

• Chemical Name: 1-CHLORO-6-PHENYLHEXANE
• CAS No.: 56644-06-5
• Molecular Formula: C12H17Cl
• Molecular Weight: 196.72
• Mol file: 56644-06-5.mol

Synonyms:6-PHENYL-N-HEXYLCHLORIDE;6-PHENYLHEXYLCHLORIDE;(6-CHLOROHEXYL)BENZENE;1-CHLORO-6-PHENYLHEXANE

Chemical Property of 1-CHLORO-6-PHENYLHEXANE

Chemical Property:

• PSA: 0.00000
• LogP: 4.02830

Purity/Quality:

98% ^*data from raw suppliers

6-Phenylhexylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Phenylhexylchloride (cas# 56644-06-5) is a compound useful in organic synthesis.

Technology Process of 1-CHLORO-6-PHENYLHEXANE

There total 16 articles about 1-CHLORO-6-PHENYLHEXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-phenyl-1-hexanol (2430-16-2) → 6-phenyl-1-hexylchloride (56644-06-5)

Guidance literature:

With thionyl chloride; In chloroform; for 1h; Heating;

Reference yield: 85.0%

iodobenzene (591-50-4) + 1-bromo-6-chlorohexane (6294-17-3) → 6-phenyl-1-hexylchloride (56644-06-5)

Guidance literature:

1-bromo-6-chlorohexane; With iodine; zinc; In N,N-dimethyl acetamide; at 80 ℃;

iodobenzene; bis(triphenylphosphine)nickel(II) chloride; In N,N-dimethyl acetamide; Further stages.;

DOI:10.1021/ol0272693

Reference yield: 84.0%

5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) + 4-methylbenzenesulfonic acid 6-chlorohexyl ester (71042-21-2) → 6-phenyl-1-hexylchloride (56644-06-5)

Guidance literature:

With copper(l) iodide; lithium tert-butoxide; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201008007

upstream raw materials:

6-phenyl-1-hexanol

1,6-dichlorohexane

benzene

iodobenzene

Downstream raw materials:

7-phenylheptanenitrile

hexylbenzene

2-(6-phenylhexyl)-1,3-dihydro-1,3-dioxo-2H-isoindole

5-(3,5-dichlorophenylthio)-2-hydroxymethyl-4-isopropyl-1-(6-phenylhexyl)-1H-imidazole

Refernces

• 1、 Bai, Songlin,Gao, Yadong,Jiang, Chao,Liu, Xiaolei,Qi, Xiangbing,Wang, Jing,Wu, Qingcui,Yang, Chao. "Visible-Light-Induced Nickel-Catalyzed Cross-Coupling with Alkylzirconocenes from Unactivated Alkenes". supporting information. p. 675 - 688. Retrieved 2020/03/11.
• 2、 Montanari, Serena,Scalvini, Laura,Bartolini, Manuela,Belluti, Federica,Gobbi, Silvia,Andrisano, Vincenza,Ligresti, Alessia,Di Marzo, Vincenzo,Rivara, Silvia,Mor, Marco,Bisi, Alessandra,Rampa, Angela. "Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents". supporting information. p. 6387 - 6406. Retrieved 2016/07/26.