Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride

Base Information

• Chemical Name: Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride
• CAS No.: 61367-16-6
• Molecular Formula: C8H15 N O2 . Cl H
• Molecular Weight: 193.674
• Hs Code.: 2922499990
• Mol file: 61367-16-6.mol

Synonyms:Cyclohexanecarboxylicacid, 4-amino-, methyl ester, hydrochloride, cis- (9CI); Methylcis-4-aminocyclohexanecarboxylate hydrochloride;cis-4-Aminocyclohexanecarboxylic acid methyl ester hydrochloride

Chemical Property of Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride

Chemical Property:

• Melting Point: 188°C(lit.)
• PSA: 52.32000
• LogP: 2.17920
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl cis-4-aminocyclohexanecarboxylate HCl

Technology Process of Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride

There total 5 articles about Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

methanol (67-56-1) + trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7) → trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride (61367-07-5,61367-16-6,100707-54-8)

Guidance literature:

With thionyl chloride; at -10 ℃; for 1.5h; Reflux;

Reference yield: 91.0%

methanol (67-56-1) + cis-4-aminocyclohexane-1-carboxylic acid (3685-23-2) → cis-4-aminocyclohexanecarboxylic acid methyl ester hydrochloride (61367-16-6)

Guidance literature:

With thionyl chloride; for 2h; Ambient temperature;

DOI:10.1016/S0022-1139(96)03457-4

Reference yield:

methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate (146307-51-9) → trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride (61367-07-5,61367-16-6,100707-54-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 19h;

upstream raw materials:

methanol

cis-4-aminocyclohexane-1-carboxylic acid

4-amino-benzoic acid

methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate

Downstream raw materials:

2-aza-bicyclo[2.2.2]octan-3-one

cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester

methyl trans-4-(morpholin-4-ylcarbonyl)cyclohexane carboxylate

methyl trans-4-(pyrrolidin-1-ylcarbonyl)cyclohexane carboxylate

Refernces

• 1、 -. "NITROGENOUS FUSED BICYCLIC COMPOUND". Page/Page column 56. . Retrieved 2010/11/26.
• 2、 -. "Heterocycle derivatives and drugs". . . Retrieved 2008/06/13.