5-methoxy-2,3-diphenyl-1H-indole

Base Information

• Chemical Name: 5-methoxy-2,3-diphenyl-1H-indole
• CAS No.: 88530-86-3
• Molecular Formula: C21H17 N O
• Molecular Weight: 299.372
• Mol file: 88530-86-3.mol

Synonyms:Indole,5-methoxy-2,3-diphenyl- (6CI); 2,3-Diphenyl-5-methoxyindole;5-Methoxy-2,3-diphenylindole; NSC 76681

Chemical Property of 5-methoxy-2,3-diphenyl-1H-indole

Chemical Property:

• Vapor Pressure: 5.06E-09mmHg at 25°C
• Boiling Point: 483.1°C at 760 mmHg
• Flash Point: 172.2°C
• Density: 1.167g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methoxy-2,3-diphenyl-1H-indole

There total 21 articles about 5-methoxy-2,3-diphenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxyphenylhydrazine hydrochloride (19501-58-7) + diphenyl acetylene (501-65-5) → 5-methoxy-2,3-diphenyl-1H-indole (88530-86-3)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium acetate; isobutyraldehyde; In methanol; at 80 ℃; for 12h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201304302

Reference yield: 92.0%

diphenyl acetylene (501-65-5) + N’-(4-methoxyphenyl)acetohydrazide (17473-78-8) → 5-methoxy-2,3-diphenyl-1H-indole (88530-86-3)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid; In 1,2-dichloro-ethane; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201306098

Reference yield: 90.0%

4-methoxy-aniline (104-94-9) + diphenyl acetylene (501-65-5) → 5-methoxy-2,3-diphenyl-1H-indole (88530-86-3)

Guidance literature:

4-methoxy-aniline; diphenyl acetylene; With Cp*Rh(H₂O)₃(OTf)₂; oxygen; acetic anhydride; In tert-Amyl alcohol; at 40 ℃; for 24h; under 760.051 Torr; Inert atmosphere; Schlenk technique;

With sodium hydroxide; In methanol; tert-Amyl alcohol; at 20 ℃; for 1h;

DOI:10.1039/c3cc49751h

upstream raw materials:

2-hydroxy-2-phenylacetophenone

4-methoxy-aniline

deoxybenzoin p-methoxyphenylhydrazone

phenyl benzyl ketone

Downstream raw materials:

5-methoxy-2,3-diphenyl-7-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)indole

2,3-diphenyl-5-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-acetyl-β-D-glucopyranosyloxy>indole

7-(D-glucopyranosyl)-5-methoxy-2,3-diphenylindole

2-(1H-Benzoimidazol-2-ylamino)-1-(5-methoxy-2,3-diphenyl-indol-1-yl)-ethanone