5-Androsten-17beta-ol-3-one

Base Information

• Chemical Name: 5-Androsten-17beta-ol-3-one
• CAS No.: 571-25-5
• Molecular Formula: C19H28O2
• Molecular Weight: 288.43
• Mol file: 571-25-5.mol

Synonyms:2-Propenoic acid,3-(5-pentyl-2-thienyl);3-(5-pentyl-thiophen-2-yl)-acrylic acid;5-Amyl-thienyl(2)acrylsaeure;

Chemical Property of 5-Androsten-17beta-ol-3-one

Chemical Property:

• Melting Point: 160-168 °C
• Boiling Point: 425.3±45.0 °C(Predicted)
• PKA: 15.07±0.60(Predicted)
• PSA: 37.30000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 3.87920

Purity/Quality:

95%-98% ^*data from raw suppliers

5-ANDROSTEN-17BETA-OL-3-ONE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (17β)?-?17-?Hydroxyandrost-?5-?en-?3-?one is a reagent in the synthesis of new hedgehog signaling inhibitors which may be used in cancer treatments.

Technology Process of 5-Androsten-17beta-ol-3-one

There total 1 articles about 5-Androsten-17beta-ol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

C27H35NO5 (85674-79-9) → testosterone (58-22-0) + 17β-hydroxyandrost-5-en-3-one (571-25-5)

Guidance literature:

In benzene; for 6h; Irradiation;

Reference yield:

17β-hydroxyandrost-5-en-3-one (571-25-5) → 19-nortestosterone (434-22-0)

Guidance literature:

With ketosteroid isomerase; Catalytic behavior; Enzymatic reaction;

DOI:10.1126/science.1259802

Reference yield:

17β-hydroxyandrost-5-en-3-one (571-25-5) → 17β-hydroxy-4,4-dimethylandrost-5-en-3-one (5062-44-2)

Guidance literature:

With potassium; Yield given. Multistep reaction; 1.) tert-butyl alcohol, 15 min, reflux, 2.) tert-butyl alcohol, room temp. 15 min, reflux 15 min;

DOI:10.1021/jo00319a017

upstream raw materials:

C₂₇H₃₅NO₅

Downstream raw materials:

17β-hydroxy-4,4-dimethylandrost-5-en-3-one

19-nortestosterone

Refernces