Ethyl 2-(3-formylphenoxy)acetate

Base Information

• Chemical Name: Ethyl 2-(3-formylphenoxy)acetate
• CAS No.: 51264-68-7
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID10363476
• Nikkaji Number: J2.046.034B
• Wikidata: Q82147185
• Mol file: 51264-68-7.mol

Synonyms:ethyl 2-(3-formylphenoxy)acetate;51264-68-7;ETHYL 3-FORMYLPHENOXYACETATE;ethyl (3-formylphenoxy)acetate;(3-Formyl-phenoxy)-acetic acid ethyl ester;3-(ethoxycarbonylmethoxy)benzaldehyde;ethyl-3-formylphenoxyacetate;SCHEMBL385690;DTXSID10363476;BCA26468;MFCD04227168;3-(ethoxycarbonylmethoxy) benzaldehyde;3-Formylphenoxyacetic acid ethyl ester;AKOS000184544;AS-61177;BB 0243295;CS-0319944;F87453

Chemical Property of Ethyl 2-(3-formylphenoxy)acetate

Chemical Property:

• Vapor Pressure: 0.000298mmHg at 25°C
• Refractive Index: 1.5320
• Boiling Point: 148-150°C 2mm
• Flash Point: 148-150°C/2mm
• PSA: 52.60000
• Density: 1.169g/cm³
• LogP: 1.44100
• Sensitive.: Air Sensitive
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 208.07355886
• Heavy Atom Count: 15
• Complexity: 215

Purity/Quality:

98%Min ^*data from raw suppliers

ETHYL3-FORMYLPHENOXYACETATE ^*data from reagent suppliers

Safty Information:

• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=CC(=C1)C=O

Technology Process of Ethyl 2-(3-formylphenoxy)acetate

There total 5 articles about Ethyl 2-(3-formylphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl bromoacetate (105-36-2) + meta-hydroxybenzaldehyde (100-83-4) → ethyl 2-(3-formylphenoxy)acetate (51264-68-7)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; Heating;

DOI:10.1016/j.bmcl.2003.11.072

Reference yield: 96.0%

chloroacetic acid ethyl ester (105-39-5) + meta-hydroxybenzaldehyde (100-83-4) → ethyl 2-(3-formylphenoxy)acetate (51264-68-7)

Guidance literature:

meta-hydroxybenzaldehyde; With potassium carbonate; sodium iodide; In acetonitrile; for 0.5h; Reflux; Inert atmosphere;

chloroacetic acid ethyl ester; In acetonitrile; for 3h; Reflux; Inert atmosphere;

Reference yield: 27.9%

→ ethyl 2-(3-formylphenoxy)acetate (51264-68-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

upstream raw materials:

ethanol

2-(3-formylphenoxy)acetic acid

chloroacetic acid ethyl ester

meta-hydroxybenzaldehyde

Downstream raw materials:

[3-(2-nitro-vinyl)-phenoxy]-acetic acid ethyl ester

3-hydroxymethyl-1-ethoxycarbonylmethoxybenzene

Z-5-[3-(ethoxycarbonylmethoxy)benzylidene]-2-thiohydantoin

C₁₄H₁₆O₄