(4-Hydroxyphenyl)diphenylphosphine

Base Information

• Chemical Name: (4-Hydroxyphenyl)diphenylphosphine
• CAS No.: 5068-21-3
• Molecular Formula: C18H15OP
• Molecular Weight: 278.29
• DSSTox Substance ID: DTXSID40391505
• Nikkaji Number: J1.173.894J
• ChEMBL ID: CHEMBL4644035
• Mol file: 5068-21-3.mol

Synonyms:(4-Hydroxyphenyl)diphenylphosphine;5068-21-3;4-(Diphenylphosphino)phenol;4-diphenylphosphanylphenol;(p-Hydroxyphenyl)diphenylphosphine;p-diphenylphosphinophenol;DIPHENYL-(4-HYDROXYPHENYL)PHOSPHINE;SCHEMBL650394;CHEMBL4644035;DTXSID40391505;MFCD00775358;(4-Hydroxyphenyl)diphenylphosphine, 98%;CS-0214442;FT-0635531

Chemical Property of (4-Hydroxyphenyl)diphenylphosphine

Chemical Property:

• Vapor Pressure: 3.36E-07mmHg at 25°C
• Melting Point: 105-110 °C(lit.)
• Boiling Point: 406.8°C at 760 mmHg
• PKA: 9.32±0.13(Predicted)
• Flash Point: 199.8°C
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 278.086052095
• Heavy Atom Count: 20
• Complexity: 255

Purity/Quality:

99% ^*data from raw suppliers

(4-Hydroxyphenyl)diphenylphosphine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=C(C=C3)O

Technology Process of (4-Hydroxyphenyl)diphenylphosphine

There total 18 articles about (4-Hydroxyphenyl)diphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(tert-butyldimethylsiloxy)phenyldiphenylphosphine (238403-27-5) → 4-(diphenylphosphanyl)phenol (5068-21-3)

Guidance literature:

With tetrabutyl ammonium fluoride;

DOI:10.1021/jo9903712

Reference yield: 93.0%

(4-Hydroxyphenyl)diphenylphosphine oxide (793-43-1) → 4-(diphenylphosphanyl)phenol (5068-21-3)

Guidance literature:

With trichlorosilane; In tetrahydrofuran; toluene; at 110 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115310

Reference yield: 92.0%

p-Iodophenol (540-38-5) + diphenylphosphane (829-85-6) → 4-(diphenylphosphanyl)phenol (5068-21-3)

Guidance literature:

palladium;

DOI:10.1002/chem.200390161

upstream raw materials:

p-Iodophenol

diphenylphosphane

4-(tert-butyldimethylsiloxy)phenyldiphenylphosphine

4-bromo-phenol

Downstream raw materials:

Mn(CO)2(η5-C5H4CH3)(P(C6H5)2(C6H4OH)

HOC₆H₄P(C₆H₅)2*Fe⁽²⁺⁾*C₅H₅^(1-)*(CH₂P(C₆H₅)2)2*PF₆^(1-)=[HOC₆H₄P(C₆H₅)2Fe(C₅H₅)((CH₂P(C₆H₅)2)2)]PF₆

[(1,5-cyclooctadiene)RhCl(PPh₂C₆H₄OH)]

6(A)-O-[4-(diphenylphosphino)phenyl]-2(A),2(B),2(C),2(D),2(E),2(F),2(G),3(B),3(C),3(D),3(E),3(F),3(G),6(B),6(C),6(D),6(E),6(F),6(G)-eicosa-O-methyl-β-cyclodextrin

Refernces

• 1、 -. "Phosphite sodium salt modified amphipathic phosphorus-containing crown macromolecule nano micelle and preparation and application thereof". Paragraph 0086; 0093. . Retrieved 2021/08/25.
• 2、 Wang, Erfei,Zhang, Jiawei,Zhong, Zhuoran,Chen, Kaixuan,Chen, Mao. "Shuttling Catalyst: Facilitating C?C Bond Formation via Cross-Couplings with a Thermoresponsive Polymeric Ligand". . p. 419 - 423. Retrieved 2020/01/08.