Methyl 2-chloro-3-hydroxybenzoate

Base Information

• Chemical Name: Methyl 2-chloro-3-hydroxybenzoate
• CAS No.: 1125632-11-2
• Molecular Formula: C8H7ClO3
• Molecular Weight: 186.59238
• Hs Code.: 2918290000
• Mol file: 1125632-11-2.mol

Synonyms:Methyl 2-chloro-3-hydroxybenzoate;BENZOIC ACID, 2-CHLORO-3-HYDROXY-, METHYL ESTER

Chemical Property of Methyl 2-chloro-3-hydroxybenzoate

Chemical Property:

• PSA: 46.53000
• LogP: 1.83220
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-chloro-3-hydroxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-chloro-3-hydroxybenzoate

There total 6 articles about Methyl 2-chloro-3-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-hydroxybenzoate (19438-10-9) → methyl 2-chloro-3-hydroxybenzoate (1125632-11-2)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; isopropylamine hydrochloride; In toluene; at 0 - 25 ℃; for 4h; Darkness;

Reference yield: 92.0%

methanol (67-56-1) + 2-chloro-3-hydroxybenzaldehyde (56962-10-8) → methyl 2-chloro-3-hydroxybenzoate (1125632-11-2)

Guidance literature:

With indium(III) triflate; Oxone; Reflux; Inert atmosphere;

Reference yield: 57.0%

methyl 3-hydroxybenzoate (19438-10-9) → 2-chloro-5-hydroxy-benzoic acid methyl ester (247092-10-0) + methyl 2-chloro-3-hydroxybenzoate (1125632-11-2)

Guidance literature:

With N-chloro-succinimide; C₂₄H₂₀F₁₂N₄OS; In chloroform-d1; at 20 ℃; for 20h; regioselective reaction;

DOI:10.1021/acs.orglett.6b02650

upstream raw materials:

methanol

2-Chloro-3-hydroxy benzoic acid

methyl 3-hydroxybenzoate

2-chloro-3-hydroxybenzaldehyde

Downstream raw materials:

2-Chloro-3-methoxybenzoic acid methyl ester

4-bromo-2-chloro-3-hydroxybenzoic acid methyl ester