56961-30-9

Basic information

• Product Name: 2-CHLORO-5-HYDROXYBENZOIC ACID
• Synonyms: 2-Chloro-5-hydroxybenzene carboxylic acid;2-Chloro-5-hydroxybenzoic acid 98%;3-Carboxy-4-chlorophenol;2-CHLORO-5-HYDROXYBENZOIC ACID
• CAS NO: 56961-30-9
• Molecular Formula: C₇H₅ClO₃
• Molecular Weight: 172.57
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 56961-30-9.mol
• Article Data: 16

Chemical Properties

• Melting Point: 178-180°C
• Boiling Point: 364.5 °C at 760 mmHg
• Flash Point: 174.3 °C
• Appearance: /
• Density: 1.536 g/cm³
• Vapor Pressure: 5.92E-06mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.78±0.25(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-HYDROXYBENZOIC ACID(56961-30-9)
• EPA Substance Registry System: 2-CHLORO-5-HYDROXYBENZOIC ACID(56961-30-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 56961-30-9(Hazardous Substances Data)

Usage

Uses

2-Chloro-5-hydroxybenzoic Acid acts as a reagent for the synthesis, structure-activity relationship, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.

InChI:InChI=1/C7H5ClO3/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3,9H,(H,10,11)

Upstream product

• 7781-98-8 ethyl-3-hydroxybenzoate 
• 99-06-9 3-Carboxyphenol 
• 67-56-1 methanol 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 59-50-7 4-Chloro-3-methylphenol 
• 10025-87-3 trichlorophosphate 
• 106-48-9 4-chloro-phenol 
• 19094-56-5 2-chloro-5-iodobenzoic acid 
• 54810-63-8 methyl (2-chloro-5-methoxy)benzoate 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 6280-89-3 2-chloro-5-methoxybenzoic acid 
• 89-54-3 2-chloro-5-aminobenzoic acid 

Downstream Products

• 102873-26-7 2-chloro-5-hydroxy-benzoic acid isopentyl ester 
• 105908-98-3 2-chloro-5-hydroxy-benzoic acid butyl ester 
• 98555-62-5 2-chloro-5-hydroxy-4-nitro-benzoic acid 
• 247092-10-0 2-chloro-5-hydroxy-benzoic acid methyl ester 

Relevant articles and documents

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Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air

L-(?)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95percent ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.

The role of polycyclic frameworks in modulating P2X7 receptor function

Herein we describe our recent attempts to target the P2X7 receptor for potential treatment of neurological disorders. This work focusses on different polycycles including carborane, adamantane or cubane, joined by either a cyanoguanidine or an amide linker to phenyl or isoquinoline moieties. We have demonstrated the superiority of the adamantyl moiety over other polycycles in terms of synthetic accessibility and biological (cellular) activity. We have also shown that an amide or cyanoguanidine linker can greatly alter the biological activity of compounds. This SAR study provides important insights into the types of functionality required to target the P2X7 receptor.