Z-TRP-NHME

Base Information

Chemical Name:Z-TRP-NHME
CAS No.:53708-61-5
Molecular Formula:C20H21N3O3
Molecular Weight:351.405
Hs Code.:2933990090
Mol file:53708-61-5.mol

Synonyms:N-ALPHA-CARBOBENZOXY-L-TRYPTOPHAN METHYL AMIDE;Z-L-TRYPTOPHAN METHYLAMIDE;Z-TRP-NHME;N-.ALPHA.-CBZ-L-TRYPTOPHAN METHYL AMIDE

Suppliers and Price of Z-TRP-NHME

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
Z-TRP-NHME 95.00%
5MG
$ 498.88

Total 7 raw suppliers

Chemical Property of Z-TRP-NHME

Chemical Property:

PSA：83.22000
LogP:3.53320

Purity/Quality:

99% ^*data from raw suppliers

Z-TRP-NHME 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Z-TRP-NHME

There total 1 articles about Z-TRP-NHME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 74-89-5
methylamine

: 7432-21-5
N-carbobenzyloxy-L-tryptophane

: 53708-61-5
Z-Trp-NH-CH₃

Guidance literature:: With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -15 - 22 ℃; for 0.5h;

Reference yield:

: 53708-61-5
Z-Trp-NH-CH₃

: 77549-21-4
Z-Orn(Msc)-Trp-NH-CH₃

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) H₂, conc. HCl, 2.) pyridine / palladium on charcoal / methanol

2: 87.7 percent / triethylamine / ethyl acetate

With pyridine; hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethyl acetate;

Reference yield:

: 53708-61-5
Z-Trp-NH-CH₃

: (S)-1-(3,5-dichloro-benzenesulfonyl)-piperidine-2-carboxylic acid [(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 1.5 h

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 17 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

4: triethylamine / tetrahydrofuran; dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;