sym.-Dimethylcitrat

Base Information

• Chemical Name: sym.-Dimethylcitrat
• CAS No.: 53798-96-2
• Molecular Formula: C8H12O7
• Molecular Weight: 220.179
• Hs Code.: 2918990090
• Mol file: 53798-96-2.mol

Synonyms:sym.-Dimethylcitrat

Chemical Property of sym.-Dimethylcitrat

Chemical Property:

• Melting Point: 123-125?C
• Boiling Point: 405.1±45.0 °C(Predicted)
• PKA: 2.75±0.28(Predicted)
• PSA: 110.13000
• Density: 1.378±0.06 g/cm3(Predicted)
• LogP: -1.07170
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Acetonitrile (Slightly), DMSO, Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

1,5-DimethylCitrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected Citrate, and intermediate in the production of Mosapride Citric Amide

Technology Process of sym.-Dimethylcitrat

There total 12 articles about sym.-Dimethylcitrat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + citric acid (77-92-9,906507-37-7) → 1,5-dimethyl citrate (53798-96-2)

Guidance literature:

With boric acid; In acetone; at 20 ℃; for 72h;

Reference yield:

→ 1,5-dimethyl citrate (53798-96-2)

Guidance literature:

With sodium hydroxide;

Reference yield:

C26H31NO9 → 1,5-dimethyl citrate (53798-96-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1002/jps.2600760115

upstream raw materials:

(5-oxo-[1,3]dioxolane-4,4-diyl)-bis-acetic acid dimethyl ester

methanol

citric acid

sulfuric acid

Downstream raw materials:

acetonedicarboxylic acid

citric acid α,α'-dibenzyl ester

β-citryl-L-glutamic acid

trimethyl citrate

Refernces

• 1、 Silver,Sundholm. "Solid-state esterification of codeine phosphate by the acid constituent of effervescent tablets". . p. 53 - 55. Retrieved 1987.
• 2、 Md-Saleh, Siti R,Chilvers, Emily C.,Kerr, Kevin G.,Milner, Stephen J.,Snelling, Anna M.,Weber, Jan P.,Thomas, Gavin H.,Duhme-Klair, Anne-Kathrin,Routledge, Anne. "Synthesis of citrate-ciprofloxacin conjugates". scheme or table. p. 1496 - 1498. Retrieved 2009/11/30.
• 3、 Guo, Hongyan,Naser, Saleh A.,Ghobrial, George,Phanstiel IV, Otto. "Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria". . p. 2056 - 2063. Retrieved 2007/10/03.