1-(2-Amino-4-chlorophenyl)-2-chloroethanone

Base Information

Chemical Name:1-(2-Amino-4-chlorophenyl)-2-chloroethanone
CAS No.:64605-37-4
Molecular Formula:C8H7 Cl2 N O
Molecular Weight:204.056
Hs Code.:2922399090
DSSTox Substance ID:DTXSID30499766
Wikidata:Q82350835
Mol file:64605-37-4.mol

Synonyms:64605-37-4;1-(2-Amino-4-chlorophenyl)-2-chloroethanone;1-(2-AMINO-4-CHLOROPHENYL)-2-CHLORO-ETHANONE;1-(2-Amino-4-chlorophenyl)-2-chloroethan-1-one;Ethanone, 1-(2-amino-4-chlorophenyl)-2-chloro- (9CI);1-(2'-Amino-2,4'-dichlorophenyl)ethan-1-one;SCHEMBL4043568;DTXSID30499766;VDLXWVJCSVAOKZ-UHFFFAOYSA-N;1-(2 inverted exclamation mark -Amino-2,4 inverted exclamation mark -dichlorophenyl)ethan-1-one;FT-0661722;1-(2-amino-4-chloro-phenyl)-2-chloro-ethanone

Suppliers and Price of 1-(2-Amino-4-chlorophenyl)-2-chloroethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2’-Amino-2,4’-dichlorophenyl)ethan-1-one
10mg
$ 165.00

Total 2 raw suppliers

Chemical Property of 1-(2-Amino-4-chlorophenyl)-2-chloroethanone

Chemical Property:

Melting Point:126-128 °C
Boiling Point:355.8±27.0 °C(Predicted)
PKA:-0.99±0.10(Predicted)
PSA：43.09000
Density:1.392±0.06 g/cm3(Predicted)
LogP:2.92490
Solubility.:Dichloromethane, Ethyl Acetate
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:202.9904692
Heavy Atom Count:12
Complexity:174

Purity/Quality:

99% ^*data from raw suppliers

1-(2’-Amino-2,4’-dichlorophenyl)ethan-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)N)C(=O)CCl
Uses Kynurenine (K661000) derivatives. Inhibitor of rat brain kynurenine aminotransferase.

Technology Process of 1-(2-Amino-4-chlorophenyl)-2-chloroethanone

There total 4 articles about 1-(2-Amino-4-chlorophenyl)-2-chloroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 68095-20-5
N-[5-Chloro-2-(2-chloro-acetyl)-phenyl]-acetamide

: 64605-37-4
1-(2-amino-4-chlorophenyl)-2-chloroethan-1-one

Guidance literature:: N-[5-Chloro-2-(2-chloro-acetyl)-phenyl]-acetamide; With hydrogenchloride; water; In ethanol; for 1h; Reflux;

With sodium hydroxide; In ethanol; water; pH=Ca. 9;
DOI:10.1016/j.bmc.2010.06.040

Reference yield: 49.0%

: 107-14-2
chloroacetonitrile

: 108-42-9
3-chloro-aniline

: 64605-37-4
1-(2-amino-4-chlorophenyl)-2-chloroethan-1-one

Guidance literature:: chloroacetonitrile; 3-chloro-aniline; With aluminum (III) chloride; boron trichloride; In toluene; at -5 - 70 ℃;

With hydrogenchloride; water; In toluene; at 50 ℃; for 0.5h;

Reference yield:

: 107-14-2
chloroacetonitrile

: 108-42-9
3-chloro-aniline

: 64605-37-4
1-(2-amino-4-chlorophenyl)-2-chloroethan-1-one

: 64605-39-6
6-chloro-2-amino-α-chloroacetophenone

Guidance literature:: With aluminum (III) chloride; boron trichloride - methyl sulfide complex; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2010.06.040