4-Methylpyridine-2-carboxamide

Base Information

• Chemical Name: 4-Methylpyridine-2-carboxamide
• CAS No.: 54089-04-2
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90467582
• Nikkaji Number: J3.523.993F
• Wikidata: Q82294596
• Mol file: 54089-04-2.mol

Synonyms:4-methylpyridine-2-carboxamide;54089-04-2;4-Methylpicolinamide;2-Pyridinecarboxamide,4-methyl-(9CI);4-methyl-pyridine-2-carboxylic acid amide;2-Pyridinecarboxamide, 4-methyl-;SCHEMBL106576;DTXSID90467582;VEDSTRYKPBORIS-UHFFFAOYSA-N;MFCD08062672;AKOS006286678;SB53069;TS-01751;CS-0453415;FT-0767412

Chemical Property of 4-Methylpyridine-2-carboxamide

Chemical Property:

• PSA: 55.98000
• LogP: 1.18920
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 136

Purity/Quality:

99%, ^*data from raw suppliers

4-Methylpyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)C(=O)N

Technology Process of 4-Methylpyridine-2-carboxamide

There total 8 articles about 4-Methylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

picoline (108-89-4) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-methylpyridine-2-carboxamide (54089-04-2)

Guidance literature:

With dipotassium peroxodisulfate; oxygen; sodium formate; silver nitrate; In water; at 80 ℃; for 3h; regioselective reaction; Schlenk technique;

DOI:10.1055/s-0035-1561975

Reference yield: 86.0%

2-Bromo-4-picoline (4926-28-7) + dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) → 4-methylpyridine-2-carboxamide (54089-04-2)

Guidance literature:

With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90 ℃; for 3h; Sealed tube;

DOI:10.1016/j.tetlet.2015.06.054

Reference yield: 20.0%

methanol (67-56-1) + nicotinamide (98-92-0,1255150-40-3) → 4-methylpyridine-2-carboxamide (54089-04-2)

Guidance literature:

With sulfuric acid; Irradiation;

DOI:10.1246/bcsj.61.2837

upstream raw materials:

pyridine-2-carboxylic acid amide

methanol

2-Cyano-4-methylpyridin

nicotinamide

Downstream raw materials:

C₂₄H₂₇N₅⁽²⁺⁾*2I^(1-)