Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl-

Base Information

• Chemical Name: Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl-
• CAS No.: 515863-54-4
• Molecular Formula: C7H12N2OS
• Molecular Weight: 172.25
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID90476013
• Nikkaji Number: J1.841.912B
• Wikidata: Q82306903
• Mol file: 515863-54-4.mol

Synonyms:515863-54-4;Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl-;Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl-;DTXSID90476013

Chemical Property of Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl-

Chemical Property:

• PSA: 57.97000
• LogP: 0.39320
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 172.06703418
• Heavy Atom Count: 11
• Complexity: 191

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(=O)N(C)C1=NCCS1

Technology Process of Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl-

There total 1 articles about Propanamide, N-(4,5-dihydro-2-thiazolyl)-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4,5-dihydro-N-methyl-2-thiazolamine (10416-51-0) + propionyl chloride (79-03-8) → N-(4,5-dihydro-thiazol-2-yl)-N-methyl-propionamide (515863-54-4)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 0.5h;

DOI:10.1016/S0040-4039(02)02414-0

Reference yield: 93.0%

benzylamine (100-46-9) + N-(4,5-dihydro-thiazol-2-yl)-N-methyl-propionamide (515863-54-4) → N-benzylpropanamide (10264-12-7)

Guidance literature:

In tetrachloromethane; at 20 ℃; for 6h;

DOI:10.1016/S0040-4039(02)02414-0

Reference yield: 88.0%

rac-methylbenzylamine (618-36-0) + N-(4,5-dihydro-thiazol-2-yl)-N-methyl-propionamide (515863-54-4) → N-[cyclopropyl(phenyl)methyl]propionamide (70623-01-7)

Guidance literature:

In tetrachloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(02)02414-0

upstream raw materials:

4,5-dihydro-N-methyl-2-thiazolamine

propionyl chloride

Downstream raw materials:

N-benzyl-N-methylpropionamide

N-[cyclopropyl(phenyl)methyl]propionamide

N-benzylpropanamide