5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-ylamine

Base Information

• Chemical Name: 5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-ylamine
• CAS No.: 59565-51-4
• Molecular Formula: C8H6FN3S
• Molecular Weight: 195.22
• Mol file: 59565-51-4.mol

Synonyms:5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-ylamine;2-Amino-5-o-fluorphenyl-1,3,4-thiadiazol;5-(2-fluorophenyl)-1,3,4-thiadiazole-2-ylamine;2-Amino-5-(2-fluorophenyl)-1,3,4-thiadiazole;

Chemical Property of 5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-ylamine

Chemical Property:

• Vapor Pressure: 2.21E-05mmHg at 25°C
• Refractive Index: 1.643
• Boiling Point: 360.5°C at 760 mmHg
• Flash Point: 171.8°C
• PSA: 80.04000
• Density: 1.423g/cm³
• LogP: 2.50760

Purity/Quality:

97% ^*data from raw suppliers

5-(2-Fluorophenyl)-1,3,4-thiadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-ylamine

There total 6 articles about 5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-(2-fluorophenylmethylene)hydrazine carbothioamide (2107-16-6) → 2-Amino-5-(2-fluorophenyl)-1,3,4-thiadiazole (59565-51-4)

Guidance literature:

With iron(III) chloride; In ethanol; Reflux;

DOI:10.1002/ardp.201400247

Reference yield: 51.0%

potassium thioacyanate (333-20-0) + N′-(2-fluorobenzylidene)-4-methylbenzenesulfonohydrazide (90555-36-5) → 2-Amino-5-(2-fluorophenyl)-1,3,4-thiadiazole (59565-51-4)

Guidance literature:

With N-chloro-succinimide; boron trifluoride diethyl etherate; In tert-butyl alcohol; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.1c01379

Reference yield: 49.2%

→ 2-Amino-5-(2-fluorophenyl)-1,3,4-thiadiazole (59565-51-4)

Guidance literature:

With trifluoroacetic acid; at 70 ℃; for 8h;

upstream raw materials:

1-(2-fluorobenzoyl)-3-thiosemicarbazide

2-(2-fluorophenylmethylene)hydrazine carbothioamide

thiosemicarbazide

o-fluoro-benzoic acid

Downstream raw materials:

(E)-N-[5-(2-Fluoro-phenyl)-[1,3,4]thiadiazol-2-yl]-3-phenyl-acrylamide