Cyclohexylguanidine monohydrochloride

Base Information

• Chemical Name: Cyclohexylguanidine monohydrochloride
• CAS No.: 2498-47-7
• Molecular Formula: C7H16ClN3
• Molecular Weight: 177.677
• European Community (EC) Number: 219-691-7
• DSSTox Substance ID: DTXSID50179694
• Mol file: 2498-47-7.mol

Synonyms:2498-47-7;1-Cyclohexylguanidine hydrochloride;Cyclohexylguanidine monohydrochloride;N-cyclohexylguanidine hydrochloride;Cyclohexylguanidine HCl;2-cyclohexylguanidine;hydrochloride;EINECS 219-691-7;N-Cyclohexyl-guanidine hydrochloride;C7H15N3.ClH;Cyclohexylguanidinhydrochlorid;C7-H15-N3.Cl-H;SCHEMBL16702587;DTXSID50179694;CAA49847;MFCD09800608;AKOS016845957;TS-00182;CS-0323869;N-Cyclohexylguanidine hydrochloride, AldrichCPR

Chemical Property of Cyclohexylguanidine monohydrochloride

Chemical Property:

• Melting Point: 224-226 °C
• Boiling Point: 279oC at 760mmHg
• Flash Point: 122.6oC
• PSA: 61.90000
• LogP: 2.79510
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 177.1032752
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

99% ^*data from raw suppliers

N-CyclohexylguanidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)N=C(N)N.Cl

Technology Process of Cyclohexylguanidine monohydrochloride

There total 5 articles about Cyclohexylguanidine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-[1-(1H-pyrazol-1-yl-iminomethyl)triazen-3-yl]phenyl-cellulose + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylguanidine hydrochloride (2498-47-7)

Guidance literature:

4-[1-(1H-pyrazol-1-yl-iminomethyl)triazen-3-yl]phenyl-cellulose; cyclohexylamine; In ethanol; for 12h; Heating;

With hydrogenchloride; In water; for 3h;

DOI:10.1021/ol047926m

Reference yield: 95.0%

N,N′-bis(tert-butoxycarbonyl)-N′′-cyclohexylguanidine (158478-70-7) → N-cyclohexylguanidine hydrochloride (2498-47-7)

Guidance literature:

With tin(IV) chloride; In ethyl acetate; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(97)10148-4

Reference yield: 93.0%

cyclohexylamine (108-91-8,157973-60-9) + 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3) → N-cyclohexylguanidine hydrochloride (2498-47-7)

Guidance literature:

In neat (no solvent); at 25 ℃; for 1.5h; Time; Sonication;

DOI:10.1016/j.tet.2018.06.057

upstream raw materials:

CYANAMID

cyclohexylamine

1H-pyrazole-1-carboximidamide hydrochloride

N,N′-bis(tert-butoxycarbonyl)-N′′-cyclohexylguanidine

Downstream raw materials:

N-(cyclohexylamino-methyl-[1,3,5]triazin-2-yl)-acetamide

N-cyclohexylquinazolin-2-amine

2-Amino-1-cyclohexyl-5,6-dihydro-4(1H)-pyrimidinon

N-cyclohexylquanidine