Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

Article abstract of DOI:10.1039/b815077j

A new, highly efficient, all-solid-phase synthesis of argifin, a natural product cyclic pentapeptide chitinase inhibitor, is reported. The synthesis features attachment of an orthogonally protected Asp residue to the solid support and assembly of the line