Benzeneacetonitrile, -alpha--hydroxy-2,4,6-trimethyl-, (-alpha-R)- (9CI)

Base Information

• Chemical Name: Benzeneacetonitrile, -alpha--hydroxy-2,4,6-trimethyl-, (-alpha-R)- (9CI)
• CAS No.: 545386-91-2
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 545386-91-2.mol

Synonyms:Benzeneacetonitrile, -alpha--hydroxy-2,4,6-trimethyl-, (-alpha-R)- (9CI)

Chemical Property of Benzeneacetonitrile, -alpha--hydroxy-2,4,6-trimethyl-, (-alpha-R)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetonitrile, -alpha--hydroxy-2,4,6-trimethyl-, (-alpha-R)- (9CI)

There total 5 articles about Benzeneacetonitrile, -alpha--hydroxy-2,4,6-trimethyl-, (-alpha-R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

potassium cyanide + mesytaldehyde (487-68-3) → 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile (49685-65-6,545386-91-2)

Guidance literature:

With carbon dioxide; In ethanol; at 20 ℃; for 18h; under 760.051 Torr; Sealed tube;

DOI:10.1002/chem.202003623

Reference yield: 90.0%

mesytaldehyde (487-68-3) + trimethylsilyl cyanide (7677-24-9) → 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile (49685-65-6,545386-91-2) + 2-mesityl-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:

With trimethylsilyl bis(trifluoromethanesulfonyl)imide; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1080/00397919608003546

Reference yield:

mesytaldehyde (487-68-3) → 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile (49685-65-6,545386-91-2)

Guidance literature:

With potassium cyanide; ammonium chloride; Petroleum ether; weiteres Reagens: Wasser;

DOI:10.1021/ja01259a071

upstream raw materials:

mesytaldehyde

hydrogen cyanide

trimethylsilyl cyanide

Downstream raw materials:

(R)-[(S)-Methoxycarbonyl-(2,4,6-trimethyl-phenyl)-methoxy]-(2,4,6-trimethyl-phenyl)-acetic acid methyl ester

Refernces

• 1、 Kim, Kicheol,Moeljadi, Adhitya Mangala Putra,Hirao, Hajime,Hong, Soon Hyeok. "Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex". supporting information. p. 3292 - 3298. Retrieved 2017/09/06.
• 2、 Kaur, Harpinder,Kaur, Gurmeet,Trehan, Sanjay. "Trimethylsilyl bis(fluorosulfonyl)imide: An efficient catalyst for the addition of trimethylsilyl cyanide to carbonyl compounds". . p. 1925 - 1929. Retrieved 2007/10/03.