2-(2,4-Difluorophenyl)-isonicotinic acid

Base Information

Chemical Name:2-(2,4-Difluorophenyl)-isonicotinic acid
CAS No.:500586-44-7
Molecular Formula:C₁₂H₈ClNO₂
Molecular Weight:233.654
Hs Code.:2933399090
Mol file:500586-44-7.mol

Synonyms:2-(2,4-Difluorophenyl)-isonicotinic acid;2-(2,4-Dimethoxyphenyl)-isonicotinic acid;2-(2,6-Difluorophenyl)-isonicotinic acid;2-(2-Hydroxyphenyl)-isonicotinic acid;2-(2-Methoxypyrimidin-5-yl)-isonicotinic acid;2-(2-Trifluoromethylphenyl)-isonicotinic acid;2-(3,4-Dichlorophenyl)-isonicotinic acid;2-(3,4-Difluorophenyl)-isonicotinic acid

Suppliers and Price of 2-(2,4-Difluorophenyl)-isonicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-Chlorophenyl)isonicotinicacid
250mg
$ 180.00

Crysdot
2-(4-Chlorophenyl)-isonicotinicacid 95+%
5g
$ 772.00

AK Scientific
2-(4-Chlorophenyl)isonicotinicacid
1g
$ 394.00

Total 5 raw suppliers

Chemical Property of 2-(2,4-Difluorophenyl)-isonicotinic acid

Chemical Property:

Melting Point:263-264 °C
Boiling Point:500.1±40.0 °C(Predicted)
PKA:1.80±0.10(Predicted)
PSA：50.19000
Density:1.355±0.06 g/cm3(Predicted)
LogP:2.72500

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Chlorophenyl)isonicotinicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(4-Chlorophenyl)isonicotinic acid

Technology Process of 2-(2,4-Difluorophenyl)-isonicotinic acid

There total 4 articles about 2-(2,4-Difluorophenyl)-isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chlorophenyl)isonicotinonitrile: 1415250-86-0
2-(4-chlorophenyl)isonicotinonitrile

: 500586-44-7
2-(4-chloro-phenyl)-isonicotinic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; Reflux;
DOI:10.1021/acsmedchemlett.1c00135

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: 500586-44-7
2-(4-chloro-phenyl)-isonicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 80 °C / Inert atmosphere

2: sodium hydroxide; water / ethanol / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/acsmedchemlett.1c00135

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 500586-44-7
2-(4-chloro-phenyl)-isonicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 80 °C / Inert atmosphere

2: sodium hydroxide; water / ethanol / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/acsmedchemlett.1c00135