2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI)

Base Information

Chemical Name:2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI)
CAS No.:596817-05-9
Molecular Formula:C7H10ClFN2O2
Molecular Weight:208.6179032
Hs Code.:
Mol file:596817-05-9.mol

Synonyms:2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI)

Suppliers and Price of 2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI)

Chemical Property:

PSA：64.39000
LogP:0.73710

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI)

There total 5 articles about 2-Pyrrolidinecarboxamide, 1-(chloroacetyl)-4-fluoro-, (2S,4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 79-04-9
chloroacetyl chloride

: 426844-23-7
(2S,4S)-4-fluoropyrrolidine-2-carboxamide hydrochloride

: 596817-05-9
(2S,4S)-N-chloroacetyl-4-fluoropyrrolidine-2-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃; for 1h;

Reference yield: 85.0%

: 1235447-45-6
(2S,4S)-N-chloroacetyl-4-fluoropyrrolidine-2-carbonyl fluoride

: 596817-05-9
(2S,4S)-N-chloroacetyl-4-fluoropyrrolidine-2-carboxamide

Guidance literature:: With ammonia; In dichloromethane; water; Cooling with ice;

Reference yield:

: 55429-66-8
trimethylsilyl (2S,4R)-N-trimethylsilyl-4-(trimethylsilyloxy)pyrrolidine-2-carboxylate

: 596817-05-9
(2S,4S)-N-chloroacetyl-4-fluoropyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2: hydrogen fluoride / acetonitrile / 15 h / 20 °C / Inert atmosphere

3: 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere

4: ammonia / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice

With 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride; hydrogen fluoride; ammonia; In dichloromethane; water; acetonitrile;
DOI:10.1021/jo1025783