1-Methoxy-2-naphthalenemethanol

Base Information

• Chemical Name: 1-Methoxy-2-naphthalenemethanol
• CAS No.: 76635-76-2
• Molecular Formula: C12H12 O2
• Molecular Weight: 188.226
• European Community (EC) Number: 620-759-7
• DSSTox Substance ID: DTXSID90404250
• Nikkaji Number: J438.628K
• Wikidata: Q82208337
• Mol file: 76635-76-2.mol

Synonyms:1-Methoxy-2-naphthalenemethanol;76635-76-2;(1-methoxynaphthalen-2-yl)methanol;1-Methoxynaphthalene-2-methanol;SCHEMBL5963023;DAlc2-H_000038;DTXSID90404250;UZGZPQGJNHDHKO-UHFFFAOYSA-N;2-Hydroxymethyl-1-methoxy-naphthalene;AKOS015913017;1-Methoxy-2-naphthalenemethanol, 98%;WS-02488;D86513

Chemical Property of 1-Methoxy-2-naphthalenemethanol

Chemical Property:

• Vapor Pressure: 2.06E-05mmHg at 25°C
• Melting Point: 67-70 °C(lit.)
• Refractive Index: 1.627
• Boiling Point: 347.2°C at 760 mmHg
• PKA: 13.85±0.10(Predicted)
• Flash Point: 163.1°C
• Density: 1.166g/cm³
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 188.083729621
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methoxynaphthalene-2-methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC2=CC=CC=C21)CO

Technology Process of 1-Methoxy-2-naphthalenemethanol

There total 4 articles about 1-Methoxy-2-naphthalenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

methyl 1-methoxy-2-naphthoate (6039-59-4) → 2-(Hydroxymethyl)-1-methoxynaphthalene (76635-76-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Ambient temperature;

Reference yield: 84.3%

→ 2-(Hydroxymethyl)-1-methoxynaphthalene (76635-76-2)

Guidance literature:

Reference yield:

1-methoxy-2-naphthoic acid (883-21-6) → 2-(Hydroxymethyl)-1-methoxynaphthalene (76635-76-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

DOI:10.1021/jm00069a006

upstream raw materials:

1-methoxy-2-naphthoic acid

methyl 1-methoxy-2-naphthoate

1-hydroxy-2-naphthoic acid

Downstream raw materials:

cyclopropane carboxylic acid (1-methoxy-2-naphthyl)methyl ester

1-methoxy-2-naphthaldehyde

1-Methoxynaphthalene

2-(Phenylmethyl)-1-methoxynaphthalene

Refernces

• 1、 Ganguly, Aniruddha,Ghosh, Soumen,Kar, Samiran,Guchhait, Nikhil. "Selective fluorescence sensing of Cu(II) and Zn(II) using a simple Schiff base ligand: Naked eye detection and elucidation of photoinduced electron transfer (PET) mechanism". supporting information. p. 72 - 80. Retrieved 2015/05/19.
• 2、 Kongkathip, Ngampong,Pradidphol, Narathip,Hasitapan, Komkrit,Grigg, Ronald,Kao, Wei-Chun,Hunte, Carola,Fisher, Nicholas,Warman, Ashley J.,Biagini, Giancarlo A.,Kongsaeree, Palangpon,Chuawong, Pitak,Kongkathip, Boonsong. "Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents". scheme or table. p. 1211 - 1221. Retrieved 2010/08/07.