N,N-Dimethyl 2-pyridinecarboxamide

Base Information

Chemical Name:N,N-Dimethyl 2-pyridinecarboxamide
CAS No.:14805-91-5
Molecular Formula:C8H10 N2 O
Molecular Weight:150.18
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00879132
Nikkaji Number:J535.236C
Wikidata:Q82861183
Mol file:14805-91-5.mol

Synonyms:14805-91-5;2-Pyridinecarboxamide,N,N-dimethyl-(9CI);N,N-Dimethyl 2-pyridinecarboxamide;n,n-dimethylpyridine-2-carboxamide;SCHEMBL761925;pyridine-N,N-dimethyl formamide;DTXSID00879132;N,N-dimethyl-pyridine-2-carboxamide;AKOS008932881;2-PYRIDINECARBOXAMIDE,NN-DIMETHYL;Z32014276

Suppliers and Price of N,N-Dimethyl 2-pyridinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N,N-Dimethyl 2-pyridinecarboxamide

Chemical Property:

PSA：33.20000
LogP:0.78340
XLogP3:-0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:150.079312947
Heavy Atom Count:11
Complexity:145

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C(=O)C1=CC=CC=N1

Technology Process of N,N-Dimethyl 2-pyridinecarboxamide

There total 3 articles about N,N-Dimethyl 2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 109-04-6
2-bromo-pyridine

: 67-56-1
methanol

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 2459-07-6,260998-83-2
methyl pyridine-2-carboxylate

: 14805-91-5
N,N-dimethylpicolinamide

Guidance literature:: 2-bromo-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

methanol; Further stages;
DOI:10.1016/j.tet.2012.04.016

Reference yield: 49.0%

: 1-ethoxypyridin-1-ium tetrafluoroborate

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1903-64-6
N,N-dimethylisonicotineamide

: 14805-91-5
N,N-dimethylpicolinamide

Guidance literature:: With dipotassium peroxodisulfate; 3-(diphenylphosphoryl)-6-methoxy-1-methylquinolin-2(1H)-one; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21h; regioselective reaction; Sealed tube; Inert atmosphere; Irradiation;
DOI:10.1021/jacs.9b02013

Reference yield:

: 694-59-7
pyridine N-oxide

: 1903-64-6
N,N-dimethylisonicotineamide

: 14805-91-5
N,N-dimethylpicolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: 3-(diphenylphosphoryl)-6-methoxy-1-methylquinolin-2(1H)-one; dipotassium peroxodisulfate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 21 h / 20 °C / Sealed tube; Inert atmosphere; Irradiation

With dipotassium peroxodisulfate; 3-(diphenylphosphoryl)-6-methoxy-1-methylquinolin-2(1H)-one; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.9b02013