4-Chloro-6-methyl-2-(pyridin-4-yl)pyrimidine

Base Information

• Chemical Name: 4-Chloro-6-methyl-2-(pyridin-4-yl)pyrimidine
• CAS No.: 61310-33-6
• Molecular Formula: C10H8ClN3
• Molecular Weight: 205.647
• Hs Code.: 2933990090
• European Community (EC) Number: 878-068-3
• ChEMBL ID: CHEMBL355189
• DSSTox Substance ID: DTXSID40509300
• Wikidata: Q82366759
• Mol file: 61310-33-6.mol

Synonyms:4-chloro-6-methyl-2-(pyridin-4-yl)pyrimidine;61310-33-6;4-CHLORO-2-(4-PYRIDYL)-6-METHYL PYRIMIDINE;4-chloro-6-methyl-2-pyridin-4-ylpyrimidine;CHEMBL355189;SCHEMBL11513769;DTXSID40509300;ZSRSIZQAKUIMTE-UHFFFAOYSA-N;AKOS009579156;SB59757;CS-0045959;4-chloro-6-methyl-2-(4-pyridinyl)pyrimidine;EN300-56215;4-(6-HYDROXYHEXYLOXY)-4-METHOXYBIPHENYL;Z431782712

Chemical Property of 4-Chloro-6-methyl-2-(pyridin-4-yl)pyrimidine

Chemical Property:

• Vapor Pressure: 0.0239mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 257°C at 760 mmHg
• Flash Point: 134.1°C
• PSA: 38.67000
• Density: 1.264g/cm³
• LogP: 2.50040
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 205.0406750
• Heavy Atom Count: 14
• Complexity: 182

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-chloro-6-methyl-2-(pyridin-4-yl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)C2=CC=NC=C2)Cl

Technology Process of 4-Chloro-6-methyl-2-(pyridin-4-yl)pyrimidine

There total 7 articles about 4-Chloro-6-methyl-2-(pyridin-4-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one (59341-68-3) → 4-Chloro-6-methyl-2-(4-pyridinyl)pyrimidine (61310-33-6)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; at 150 - 170 ℃; for 6h;

DOI:10.1021/jm00349a014

Reference yield: 43.0%

6-methyl-2-(pyridin-4'-yl)pyrimidin-4(3H)-one (59341-68-3) → 4-Chloro-6-methyl-2-(4-pyridinyl)pyrimidine (61310-33-6)

Guidance literature:

With trichlorophosphate;

DOI:10.1071/CH9821203

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) + 6-methyl-2-(pyridin-4'-yl)pyrimidin-4(3H)-one (59341-68-3) → 4-Chloro-6-methyl-2-(4-pyridinyl)pyrimidine (61310-33-6)

Guidance literature:

With trichlorophosphate; In chloroform;

upstream raw materials:

6-methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one

6-methyl-2-(pyridin-4'-yl)pyrimidin-4(3H)-one

4-amidinopyridine hydrochloride

isonicotinic acid ethylester

Downstream raw materials:

4-amino-6-methyl-2-(4-pyridyl)pyrimidine