59341-68-3

Basic information

• Product Name: 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE
• Synonyms: 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE;2-(4-Pyridyl)-4-hydroxy-6-methyl pyrimidine;6-methyl-2-pyridin-4-yl-pyrimidin-4-ol;6-Methyl-2-(pyridin-4-yl)pyriMidin-4(3H)-one;BUTTPARK 18\02-36;6-methyl-2-pyridin-4-yl-1H-pyrimidin-4-one
• CAS NO: 59341-68-3
• Molecular Formula: C10H9N3O
• Molecular Weight: 187.2
• Mol File: 59341-68-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE(59341-68-3)
• EPA Substance Registry System: 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE(59341-68-3)

Safety Data

• Hazardous Substances Data: 59341-68-3(Hazardous Substances Data)

Usage

General Description

2-(4-Pyridyl)-4-hydroxy-6-Menthyl Pyrimidine is a chemical compound recognized for its pyridine and pyrimidine components. Pyridine is a basic heterocyclic organic compound, which has the chemical formula C5H5N and shares properties with aromatic compounds like benzene. The second component, pyrimidine, is also a heterocyclic aromatic organic compound and can be found in various important biomolecules like DNA, RNA, and ATP. It is central in the development of several vitamins and antibiotics. The “4-hydroxy” in the name denotes the presence of a hydroxyl (an OH) group in the 4th position of the molecule, while "6-menthyl" indicates the presence of a menthyl group (derived from menthol) in the 6th position. The specifics regarding the properties, use, or the synthesis of this exact compound are not widely available in open literature and might be subject to specific research contexts.

Upstream product

• 6345-27-3 4-amidinopyridine hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 1570-45-2 isonicotinic acid ethylester 
• 15846-25-0 ethyl ester of β-aminocrotonic acid 
• 100-48-1 pyridine-4-carbonitrile 
• 105-45-3 acetoacetic acid methyl ester 
• 33278-46-5 isonicotinamidine 

Downstream Products

• 61310-33-6 4-Chloro-6-methyl-2-(4-pyridinyl)pyrimidine 
• 61310-35-8 4-amino-6-methyl-2-(4-pyridyl)pyrimidine 

Relevant articles and documents

Novel orally active inhibitors of passive cutaneous anaphylaxis in rats: N-[2-(4-pyridinyl)-4-pyrimidinyl]ureas and dialkyl [[[2-(4-pyridinyl)-4-pyrimidinyl]amino]methylene]malonates

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Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

In an effort to identify an HIV-1 capsid assembly inhibitor with improved solubility and potency, we synthesized two series of pyrimidine analogues based on our earlier lead compound N-(4-(ethoxycarbonyl)phenyl)-2-(pyridine-4-yl)quinazoline-4-amine. In vitro binding experiments showed that our series of 2-pyridine-4-ylpyrimidines had IC50values higher than 28 μM. Our series of 2-pyridine-3-ylpyrimidines exhibited IC50values ranging from 3 to 60 μM. The congeners with a fluoro substituent introduced at the 4-N-phenyl moiety, along with a methyl at C-6, represent potent HIV capsid assembly inhibitors binding to the C-terminal domain of the capsid protein.

Unfused heterobicycles as amplifiers of phleomycin. V. A range of pyridinylpyrimidines with strongly basic side chains

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