2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE

Base Information

• Chemical Name: 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE
• CAS No.: 59341-68-3
• Molecular Formula: C10H9N3O
• Molecular Weight: 187.2
• Hs Code.: 2933990090
• Mol file: 59341-68-3.mol

Synonyms:BUTTPARK 18\02-36;2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE;2-(4-Pyridyl)-4-hydroxy-6-methyl pyrimidine

Chemical Property of 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE

Chemical Property:

• PSA: 58.90000
• LogP: 1.55260
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE

There total 8 articles about 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

isonicotinamidine (33278-46-5) + ethyl acetoacetate (141-97-9) → 6-methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one (59341-68-3)

Guidance literature:

With potassium hydroxide; In water; at 20 ℃; for 48h;

DOI:10.1039/c4ra01689k

Reference yield: 41.0%

4-amidinopyridine hydrochloride (6345-27-3,42518-06-9,61875-64-7) + acetoacetic acid methyl ester (105-45-3) → 6-methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one (59341-68-3)

Guidance literature:

With sodium methylate; In methanol; at 70 ℃; for 4h; Microwave irradiation; Sealed tube;

DOI:10.1021/acs.jmedchem.7b00441

Reference yield: 38.0%

isonicotinic acid ethylester (1570-45-2) + ethyl ester of β-aminocrotonic acid (15846-25-0) → 6-methyl-2-(pyridin-4'-yl)pyrimidin-4(3H)-one (59341-68-3)

Guidance literature:

With sodium ethanolate; In ethanol; for 3h; Heating;

DOI:10.1071/CH9821203

upstream raw materials:

4-amidinopyridine hydrochloride

ethyl acetoacetate

isonicotinamidine

acetoacetic acid methyl ester

Downstream raw materials:

4-amino-6-methyl-2-(4-pyridyl)pyrimidine

4-Chloro-6-methyl-2-(4-pyridinyl)pyrimidine