2-CHLORO-N-PROP-2-YNYLACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-PROP-2-YNYLACETAMIDE
• CAS No.: 7458-03-9
• Molecular Formula: C5H6ClNO
• Molecular Weight: 131.562
• Hs Code.: 2924199090
• Mol file: 7458-03-9.mol

Synonyms:2-CHLORO-N-PROP-2-YNYLACETAMIDE;N-(PROP-2-YNYL)-2-CHLOROACETAMIDE

Chemical Property of 2-CHLORO-N-PROP-2-YNYLACETAMIDE

Chemical Property:

• Vapor Pressure: 0.00188mmHg at 25°C
• Melting Point: 67-69
• Refractive Index: 1.473
• Boiling Point: 292°C at 760 mmHg
• PKA: 12.58±0.46(Predicted)
• Flash Point: 130.4°C
• PSA: 32.59000
• Density: 1.173g/cm³
• LogP: 0.81490

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(prop-2-yn-1-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-CHLORO-N-PROP-2-YNYLACETAMIDE

There total 4 articles about 2-CHLORO-N-PROP-2-YNYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloroacetyl chloride (79-04-9) + Propargylamine (2450-71-7) → 2-chloro-N-(prop-2-yn-1-yl)acetamide (7458-03-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.3390/molecules22050694

Reference yield: 54.0%

prop-2-yn-1-amine hydrochloride (15430-52-1) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(prop-2-yn-1-yl)acetamide (7458-03-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; for 3h;

DOI:10.1039/c1ob06162c

Reference yield:

methyl chloroacetate (96-34-4) + Propargylamine (2450-71-7) → 2-chloro-N-(prop-2-yn-1-yl)acetamide (7458-03-9)

Guidance literature:

With Candida antarctica lipase B; In tert-butyl methyl ether; at 45 ℃; for 4h; Schlenk technique; Inert atmosphere; Enzymatic reaction;

DOI:10.1039/c4ob02386b

upstream raw materials:

chloroacetyl chloride

Propargylamine

prop-2-yn-1-amine hydrochloride

methyl chloroacetate

Downstream raw materials:

N-Acetonylchloracetamid

2-chloro-N-[3-(4-chloro-quinazolin-6-yl)-prop-2-ynyl]-acetamide

C₁₆H₁₆N₂O₄

2-chloro-N-(3-{4-[3-methyl-4-(pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-acetamide hydrochloride