Ethyl 4-chloro-5-isopropylpyrrolo[2,1-F][1,2,4]triazine-6-carboxylate

Base Information

• Chemical Name: Ethyl 4-chloro-5-isopropylpyrrolo[2,1-F][1,2,4]triazine-6-carboxylate
• CAS No.: 658084-80-1
• Molecular Formula: C12H14ClN3O2
• Molecular Weight: 267.715
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00439699
• Wikidata: Q72473655
• Mol file: 658084-80-1.mol

Synonyms:658084-80-1;ETHYL 4-CHLORO-5-ISOPROPYLPYRROLO[2,1-F][1,2,4]TRIAZINE-6-CARBOXYLATE;ethyl 4-chloro-5-(propan-2-yl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate;ethyl 4-chloro-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate;DTXSID00439699;MFCD09037984;AKOS015949313;ETHYL4-CHLORO-5-ISOPROPYLPYRROLO[2,1-F][1,2,4]TRIAZINE-6-CARBOXYLATE;PB34354;ETHYL 4-CHLORO-5-ISOPROPYLPYRROLO[1,2-F][1,2,4]TRIAZINE-6-CARBOXYLATE;AS-34953;CS-0183657;FT-0684947;A867587;J-520991

Chemical Property of Ethyl 4-chloro-5-isopropylpyrrolo[2,1-F][1,2,4]triazine-6-carboxylate

Chemical Property:

• PSA: 56.49000
• LogP: 2.68280
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 267.0774544
• Heavy Atom Count: 18
• Complexity: 314

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-chloro-5-isopropylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN2C(=C1C(C)C)C(=NC=N2)Cl

Technology Process of Ethyl 4-chloro-5-isopropylpyrrolo[2,1-F][1,2,4]triazine-6-carboxylate

There total 10 articles about Ethyl 4-chloro-5-isopropylpyrrolo[2,1-F][1,2,4]triazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-(1-methylethyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic acid ethyl ester (651744-40-0) → ethyl 4-chloro-5-iso-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (658084-80-1)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 3h;

Reference yield:

ethyl 5-isopropyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (651744-40-0) → ethyl 4-chloro-5-iso-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (658084-80-1)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1016/j.bmcl.2004.12.079

Reference yield:

diethyl 3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate (651744-38-6) → ethyl 4-chloro-5-iso-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (658084-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(diphenylphosphinyl)-hydroxylamine; NaH / dimethylformamide

2: 87 percent / 165 °C

3: POCl₃ / 100 °C

With O-(diphenylphosphinyl)hydroxylamine; sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.07.027

upstream raw materials:

ethyl 5-isopropyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

diethyl 3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate

diethyl 1-amino-3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate

Ethyl isocyanoacetate

Downstream raw materials:

4-[[3-[(methoxyamino)carbonyl]-4-methylphenyl]amino]-5-(1-methylethyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

4-[[2-fluoro-5-[(methoxyamino)carbonyl]phenyl]amino]-5-(1-methylethyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

4-[[2,4-fluoro-5-[(methoxyamino)carbonyl]phenyl]amino]-5-(1-methylethyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

C₂₁H₂₅N₅O₄