Diethyl 3-isopropyl-1H-pyrrole-2,4-dicarboxylate

Base Information

Chemical Name:Diethyl 3-isopropyl-1H-pyrrole-2,4-dicarboxylate
CAS No.:651744-38-6
Molecular Formula:C13H19NO4
Molecular Weight:253.29426
Hs Code.:
Mol file:651744-38-6.mol

Synonyms:DIETHYL 3-ISOPROPYL-1H-PYRROLE-2,4-DICARBOXYLATE

Suppliers and Price of Diethyl 3-isopropyl-1H-pyrrole-2,4-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate 95+%
1g
$ 594.00

Crysdot
Diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate 97%
1g
$ 365.00

Crysdot
Diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate 97%
5g
$ 1093.00

Chemenu
diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate 95%+
1g
$ 799.00

Chemenu
diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate 95%+
100mg
$ 300.00

American Custom Chemicals Corporation
3-ISOPROPYL-1H-PYRROLE 2,4-DICARBOXYLIC ACID DIETHYL ESTER 95.00%
5MG
$ 503.32

Alichem
Diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate
5g
$ 1093.00

Total 14 raw suppliers

Chemical Property of Diethyl 3-isopropyl-1H-pyrrole-2,4-dicarboxylate

Chemical Property:

Boiling Point:397.144 °C at 760 mmHg
PKA:13.83±0.50(Predicted)
Flash Point:193.986 °C
PSA：68.39000
Density:1.118 g/cm³
LogP:2.49150

Purity/Quality:

97% ^*data from raw suppliers

Diethyl3-isopropyl-1H-pyrrole-2,4-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Diethyl 3-isopropyl-1H-pyrrole-2,4-dicarboxylate

There total 2 articles about Diethyl 3-isopropyl-1H-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2999-46-4
Ethyl isocyanoacetate

: 78-84-2
isobutyraldehyde

: 651744-38-6
diethyl 3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 19h;

Reference yield: 30.0%

: ethyl 2-isocyanoacetate

: 78-84-2
isobutyraldehyde

: 651744-38-6
diethyl 3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 50 ℃;

Reference yield:

: 651744-38-6
diethyl 3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate

: 4-[3-[(methoxyamino)carbonyl]phenoxy]-5-(1-methylethyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH; O-(diphenylphosphinyl)hydroxylamine / dimethylformamide / 2 h

2: 90 percent / 6 h / 165 °C

3: POCl₃; Et₃N / toluene / 6 h / Heating

4: 18 mg / K₂CO₃ / dimethylformamide / 18 h / 25 °C

With O-(diphenylphosphinyl)hydroxylamine; sodium hydride; potassium carbonate; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0501275