1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoro-ethanone

Base Information

Chemical Name:1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoro-ethanone
CAS No.:70211-42-6
Molecular Formula:C₈H₅F₃O₃
Molecular Weight:206.121
Hs Code.:
DSSTox Substance ID:DTXSID30445708
Wikidata:Q82264224
Mol file:70211-42-6.mol

Synonyms:1-(2,6-dihydroxyphenyl)-2,2,2-trifluoro-ethanone;70211-42-6;SCHEMBL11436501;DTXSID30445708;ZHQYBVIRGLPYMR-UHFFFAOYSA-N;1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoroethanone

Suppliers and Price of 1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoro-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoro-ethanone

Chemical Property:

PSA：57.53000
LogP:1.84280
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:206.01907850
Heavy Atom Count:14
Complexity:216

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)O)C(=O)C(F)(F)F)O

Technology Process of 1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoro-ethanone

There total 3 articles about 1-(2,6-Dihydroxyphenyl)-2,2,2-trifluoro-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193738-18-0
1-(2,6-dimethoxyphenyl)-2,2,2-trifluoroethanol

: 70211-42-6
1-(2,6-dihydroxyphenyl)trifluoromethylketone

Guidance literature:: Multi-step reaction with 2 steps

1: 90.4 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / Ambient temperature

2: 486 mg / BBr₃ / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, overnight

With boron tribromide; Dess-Martin periodane; In dichloromethane;
DOI:10.1016/S0223-5234(97)81679-0

Reference yield:

: 3392-97-0
2,6-dimethoxybenzaldehyde

: 70211-42-6
1-(2,6-dihydroxyphenyl)trifluoromethylketone

Guidance literature:: Multi-step reaction with 3 steps

1: 96.4 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature

2: 90.4 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / Ambient temperature

3: 486 mg / BBr₃ / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, overnight

With tetrabutyl ammonium fluoride; boron tribromide; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0223-5234(97)81679-0

Reference yield:

: 190665-12-4
1-(2,6-dimethoxyphenyl)trifluoromethylketone

: 70211-42-6
1-(2,6-dihydroxyphenyl)trifluoromethylketone

: 193738-66-8
2,2,2-Trifluoro-1-(2-hydroxy-6-methoxy-phenyl)-ethanone

Guidance literature:: With boron tribromide; In dichloromethane; 1.) 0 deg C, 15 min, 2.) room temperature, overnight;
DOI:10.1016/S0223-5234(97)81679-0