Technology Process of [3-Hydroxy-2-(2,2,2-trifluoro-acetyl)-phenoxy]-acetic acid methyl ester
There total 4 articles about [3-Hydroxy-2-(2,2,2-trifluoro-acetyl)-phenoxy]-acetic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 486 mg / BBr3 / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, overnight
2: K2CO3 / acetone
With
boron tribromide; potassium carbonate;
In
dichloromethane; acetone;
DOI:10.1016/S0223-5234(97)81679-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90.4 percent / Dess-Martin reagent / CH2Cl2 / 1 h / Ambient temperature
2: 486 mg / BBr3 / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, overnight
3: K2CO3 / acetone
With
boron tribromide; potassium carbonate; Dess-Martin periodane;
In
dichloromethane; acetone;
DOI:10.1016/S0223-5234(97)81679-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96.4 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature
2: 90.4 percent / Dess-Martin reagent / CH2Cl2 / 1 h / Ambient temperature
3: 486 mg / BBr3 / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, overnight
4: K2CO3 / acetone
With
tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/S0223-5234(97)81679-0
