4-((Trimethylsilyl)ethynyl)morpholine

Base Information

Chemical Name:4-((Trimethylsilyl)ethynyl)morpholine
CAS No.:64024-63-1
Molecular Formula:C9H17 N O Si
Molecular Weight:183.326
Hs Code.:2934999090
European Community (EC) Number:625-937-8
DSSTox Substance ID:DTXSID40466843
Nikkaji Number:J843.823D
Wikidata:Q82293494
Mol file:64024-63-1.mol

Synonyms:4-((trimethylsilyl)ethynyl)morpholine;64024-63-1;4-[(Trimethylsilyl)ethynyl]morpholine;trimethyl(2-morpholin-4-ylethynyl)silane;4-[2-(TRIMETHYLSILYL)ETHYNYL]MORPHOLINE;1-morpholino-2-trimethylsilylacetylene;4-TRIMETHYLSILANYLETHYNYLMORPHOLINE;1-(Trimethylsilyl)-2-morpholino acetylene;Morpholine, 4-[(trimethylsilyl)ethynyl]-;C9H17NOSi;SCHEMBL3753460;DTXSID40466843;IZXPPXICNCVEFE-UHFFFAOYSA-N;MFCD05865184;AKOS026674023;DS-9935;1-morpholino-2-trimethylsilyl acetylene;4-[(Trimethylsilyl)ethynyl]morpholine, 97%;CS-0105462;EN300-80790;C76002;A867966

Suppliers and Price of 4-((Trimethylsilyl)ethynyl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-?((Trimethylsilyl)?ethynyl)?morpholine
1g
$ 140.00

TRC
4-?((Trimethylsilyl)?ethynyl)?morpholine
5g
$ 605.00

Synthonix
4-((Trimethylsilyl)ethynyl)morpholine 95%
250mg
$ 60.00

Synthonix
4-((Trimethylsilyl)ethynyl)morpholine 95%
5g
$ 530.00

Synthonix
4-((Trimethylsilyl)ethynyl)morpholine 95%
1g
$ 130.00

Synthonix
4-((Trimethylsilyl)ethynyl)morpholine 95%
10g
$ 920.00

Crysdot
4-((Trimethylsilyl)ethynyl)morpholine 95%
100g
$ 3564.00

Crysdot
4-((Trimethylsilyl)ethynyl)morpholine 96%
100g
$ 2270.00

Crysdot
4-((Trimethylsilyl)ethynyl)morpholine 95%
25g
$ 1188.00

Crysdot
4-((Trimethylsilyl)ethynyl)morpholine 96%
25g
$ 852.00

Total 13 raw suppliers

Chemical Property of 4-((Trimethylsilyl)ethynyl)morpholine

Chemical Property:

Vapor Pressure:0.078mmHg at 25°C
Refractive Index:1.479
Boiling Point:88-90 °C9 mm Hg(lit.)
Flash Point:174 °F
PSA：12.47000
Density:0.931 g/mL at 25 °C(lit.)
LogP:1.09480
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:183.107940700
Heavy Atom Count:12
Complexity:202

Purity/Quality:

97% ^*data from raw suppliers

4-?((Trimethylsilyl)?ethynyl)?morpholine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C[Si](C)(C)C#CN1CCOCC1
Uses 4-?((Trimethylsilyl)?ethynyl)?morpholine acts as a reagent in the modification of the side chain of micromolide, an anti-tuberculosis natural product, synthesis of antifugal antibiotics (+)-desoxyfugomycin and (+)-fugomycin via sonogashira alkynylation.

Technology Process of 4-((Trimethylsilyl)ethynyl)morpholine

There total 5 articles about 4-((Trimethylsilyl)ethynyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 60506-50-5
1,1,2-Trichloro-2-morpholinoethen

: 75-77-4
chloro-trimethyl-silane

: 64024-63-1
1-morpholino-2-trimethylsilyl acetylene

Guidance literature:: 1,1,2-Trichloro-2-morpholinoethen; With n-butyllithium; In diethyl ether; hexane; at -78 - 23 ℃;

chloro-trimethyl-silane; In diethyl ether; hexane; at 23 ℃; for 15h; Further stages.;
DOI:10.1021/ja025604c

Reference yield:

: 13306-60-0
N-(trichloroacetyl)morpholine

: 64024-63-1
1-morpholino-2-trimethylsilyl acetylene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / o-xylene / 1.5 h / 150 °C

2.1: n-butyllithium / diethyl ether; hexane / -78 - 23 °C

2.2: 75 percent / diethyl ether; hexane / 15 h / 23 °C

With n-butyllithium; In diethyl ether; hexane; o-xylene;
DOI:10.1021/ja025604c

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 310905-04-5
4-((E)-1,2-Dichloro-vinyl)-morpholine

: 64024-63-1
1-morpholino-2-trimethylsilyl acetylene

Guidance literature:: 4-((E)-1,2-Dichloro-vinyl)-morpholine; With n-butyllithium; In diethyl ether; hexane; at -70 - -10 ℃;

chloro-trimethyl-silane; In diethyl ether; at -10 - 20 ℃; Further stages.;
DOI:10.1021/jo000278+