3-FLUORO-6-FORMYL-2-PICOLINE

Base Information

• Chemical Name: 3-FLUORO-6-FORMYL-2-PICOLINE
• CAS No.: 884495-34-5
• Molecular Formula: C₇H₆FNO
• Molecular Weight: 139.129
• Mol file: 884495-34-5.mol

Synonyms:5-Fluoro-6-methyl-2-pyridinecarboxaldehyde

Chemical Property of 3-FLUORO-6-FORMYL-2-PICOLINE

Chemical Property:

• Vapor Pressure: 0.809mmHg at 25°C
• Boiling Point: 182.481oC at 760 mmHg
• Flash Point: 64.163oC
• PSA: 29.96000
• Density: 1.212g/cm3
• LogP: 1.34160
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-6-methylpicolinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-6-FORMYL-2-PICOLINE

There total 5 articles about 3-FLUORO-6-FORMYL-2-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-5-fluoro-6-methyl-2-pyridine (374633-38-2) + TurboGrignard (807329-97-1) → 5-fluoro-6-methyl-2-pyridinecarboxaldehyde (884495-34-5)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 40h;

Reference yield: 80.0%

2-bromo-5-fluoro-6-methyl-2-pyridine (374633-38-2) + dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) → 5-fluoro-6-methyl-2-pyridinecarboxaldehyde (884495-34-5)

Guidance literature:

With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutylammomium bromide; sodium acetate; In acetonitrile; at 60 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.202001328

Reference yield: 75.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + 6-chloro-3-fluoro-2-methylpyridine (884494-78-4) → 5-fluoro-6-methyl-2-pyridinecarboxaldehyde (884495-34-5)

Guidance literature:

With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate; In acetonitrile; at 60 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.202001328

upstream raw materials:

N,N-dimethyl-formamide

2-bromo-5-fluoro-6-methyl-2-pyridine

TurboGrignard

dicobalt octacarbonyl

Downstream raw materials:

1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(5-fluoro-6-methylpyridin-2-yl)ethane-1,2-dione

Refernces

• 1、 -. "WDR5 INHIBITORS AND MODULATORS". Paragraph 0660. . Retrieved 2020/04/24.