884494-78-4

Basic information

• Product Name: 2-CHLORO-5-FLUORO-6-PICOLINE
• Synonyms: 2-CHLORO-5-FLUORO-6-PICOLINE;2-Chloro-5-Fluoro-6-Methylpyridine;6-Chloro-3-fluoro-2-methylpyridine;6-Chloro-3-fluoro-2-picoline;Pyridine, 6-chloro-3-fluoro-2-methyl-
• CAS NO: 884494-78-4
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• EINECS: 1312995-182-4
• Product Categories: Pyridines;Variety of halogenated heterocyclic series;Fluorine series
• Mol File: 884494-78-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 58-60°C
• Boiling Point: 163.4 °C at 760 mmHg
• Flash Point: 52.6 °C
• Appearance: /Solid
• Density: 1.264 g/cm³
• Vapor Pressure: 2.7mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.24±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-FLUORO-6-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-FLUORO-6-PICOLINE(884494-78-4)
• EPA Substance Registry System: 2-CHLORO-5-FLUORO-6-PICOLINE(884494-78-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 884494-78-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluoro-6-picoline is an organic compound with the chemical formula C6H4ClFN. It is a chlorine and fluorine-substituted derivative of pyridine, belonging to the class of picoline compounds. It is used as a building block in organic synthesis and can be found in some pharmaceutical intermediates. The compound is also used in the production of agrochemicals and other fine chemicals. It is a colorless to pale yellow liquid with a strong, pungent odor and is considered to be hazardous if ingested, inhaled, or in contact with skin.

InChI:InChI=1/C6H5ClFN/c1-4-5(8)2-3-6(7)9-4/h2-3H,1H3

Upstream product

• 164666-68-6 3-amino-6-chloro-2-methylpyridine 
• 22280-60-0 6-chloro-4-methyl-3-nitropyridine 

Downstream Products

• 1208250-43-4 3-fluoro-6-hydrazinyl-2-methylpyridine 
• 884494-76-2 2-chloro-5-?uoropyridine-6-carboxylic acid 
• 884495-34-5 5-fluoro-6-methyl-2-pyridinecarboxaldehyde 

Relevant articles and documents

6-chloro-3-fluoro-2-pyridine carboxylic acid synthesis

The invention discloses a 6-chlorine-3-fluorine-2-picolinic acid synthesis process. The main starting material is 6-chlorine-3-fluorine-2-methylpyridine.The 6-chlorine-3-fluorine-2-methylpyridine serves as the starting material, dilute sulphuric acid is a solvent, potassium dichromate is an oxidizing agent, sodium tungstate (Na2WO4 2H2O) and crown ether are a composite catalyst, after reaction is completed, a crude product is obtained through conventional post-processing, the crude product is heated to be dissolved in an alkaline aqueous solution, unreacted micro raw materials and other impurities are extracted through an organic solvent, a water layer is acidized through mineral acid, pure 6-chlorine-3-fluorine-2-picolinic acid is obtained after cooling and crystallization are carried out, the yield is high, and the quality of the product is good.