6-Chloro-3-fluoro-pyridine-2-carboxylic acid

Base Information

• Chemical Name: 6-Chloro-3-fluoro-pyridine-2-carboxylic acid
• CAS No.: 884494-76-2
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.547
• Hs Code.: 2933399990
• Mol file: 884494-76-2.mol

Synonyms:6-chloro-3-fluoropyridine-2-carboxylic acid

Chemical Property of 6-Chloro-3-fluoro-pyridine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.000649mmHg at 25°C
• Refractive Index: 1.563
• Boiling Point: 296.4 °C at 760 mmHg
• PKA: 2.34±0.10(Predicted)
• Flash Point: 133.1 °C
• PSA: 50.19000
• Density: 1.576 g/cm³
• LogP: 1.57230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-3-fluoropicolinic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-3-fluoropyridine-2-carboxylic acid

Technology Process of 6-Chloro-3-fluoro-pyridine-2-carboxylic acid

There total 2 articles about 6-Chloro-3-fluoro-pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

6-chloro-3-fluoro-2-methylpyridine (884494-78-4) → 2-chloro-5-?uoropyridine-6-carboxylic acid (884494-76-2)

Guidance literature:

With potassium dichromate; sodium tungstate (VI) dihydrate; 18-crown-6 ether; sulfuric acid; at 105 ℃; for 6h; Concentration;

Reference yield:

6-chloro-4-methyl-3-nitropyridine (22280-60-0) → 2-chloro-5-?uoropyridine-6-carboxylic acid (884494-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen; 5%-palladium/activated carbon / ethanol / 40 - 45 °C / 2250.23 - 3750.38 Torr / Autoclave

2.1: hydrogenchloride; sodium nitrite / water / 1.5 h / 0 °C

2.2: 2 h / 5 - 20 °C

3.1: sulfuric acid; 18-crown-6 ether; potassium dichromate; sodium tungstate (VI) dihydrate / 6 h / 105 °C

With hydrogenchloride; potassium dichromate; sodium tungstate (VI) dihydrate; 18-crown-6 ether; sulfuric acid; 5%-palladium/activated carbon; hydrogen; sodium nitrite; In ethanol; water;

Reference yield: 59.73%

2-chloro-5-?uoropyridine-6-carboxylic acid (884494-76-2) + methyl iodide (74-88-4) → methyl 6-chloro-3-fluoropyridine-2-carboxylate (1030829-21-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

upstream raw materials:

6-chloro-3-fluoro-2-methylpyridine

6-chloro-4-methyl-3-nitropyridine

Downstream raw materials:

methyl 6-chloro-3-fluoropyridine-2-carboxylate

Refernces