Technology Process of N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-N2-(1-methyl-ethyl)-N2-([2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)phenyl]carbonyl)glycinamide chloride
There total 6 articles about N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-N2-(1-methyl-ethyl)-N2-([2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)phenyl]carbonyl)glycinamide chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-N<sub>2</sub>-(1-methyl-ethyl)-N<sub>2</sub>-([2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)phenyl]carbonyl)glycinamide chloride](/Databaselist/images/loading.webp)
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1356146-64-9
N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-N2-(1-methyl-ethyl)-N2-([2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)phenyl]carbonyl)glycinamide chloride
- Guidance literature:
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formaldehyd; isopropylamine;
In
toluene;
at 20 ℃;
for 2h;
1-azido-17-isocyano-3,6,9,12,15-pentaoxaheptadecane; rhodamine 101;
With
hydrogenchloride;
In
methanol; water; toluene;
at 100 ℃;
for 1h;
Microwave irradiation;
DOI:10.1039/c1ob06581e
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1356146-64-9
N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-N2-(1-methyl-ethyl)-N2-([2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)phenyl]carbonyl)glycinamide chloride
- Guidance literature:
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Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 4 h / 0 - 20 °C
2.1: sodium azide; sodium hydrogencarbonate / water / 12 h / 80 °C
3.1: phosphoric acid; triphenylphosphine / diethyl ether / 24 h / 0 - 20 °C
3.2: 24 h / 0 °C
4.1: 3 h / Reflux
5.1: diisopropylamine; trichlorophosphate / dichloromethane / 2 h / 0 - 20 °C
6.1: toluene / 2 h / 20 °C
6.2: 1 h / 100 °C / Microwave irradiation
With
sodium azide; phosphoric acid; sodium hydrogencarbonate; diisopropylamine; triphenylphosphine; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
3.1: Staudinger reaction / 6.2: Ugi condensation;
DOI:10.1039/c1ob06581e
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1356146-64-9
N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-N2-(1-methyl-ethyl)-N2-([2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)phenyl]carbonyl)glycinamide chloride
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphoric acid; triphenylphosphine / diethyl ether / 24 h / 0 - 20 °C
1.2: 24 h / 0 °C
2.1: 3 h / Reflux
3.1: diisopropylamine; trichlorophosphate / dichloromethane / 2 h / 0 - 20 °C
4.1: toluene / 2 h / 20 °C
4.2: 1 h / 100 °C / Microwave irradiation
With
phosphoric acid; diisopropylamine; triphenylphosphine; trichlorophosphate;
In
diethyl ether; dichloromethane; toluene;
1.1: Staudinger reaction / 4.2: Ugi condensation;
DOI:10.1039/c1ob06581e
