[1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester

Base Information

• Chemical Name: [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester
• CAS No.: 854443-36-0
• Molecular Formula: C₆₂H₆₆F₅N₇O₁₂
• Molecular Weight: 1196.24

Synonyms:

Chemical Property of [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester

There total 1 articles about [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid (854443-33-7) + 2,3,4,5,6-pentafluorophenol (771-61-9) → [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester (854443-36-0)

Guidance literature:

With (2-chloropropyl)dimethylamine hydrochloride; In ethyl acetate; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2005.03.061

Reference yield:

[1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester (854443-36-0) → (S)-1-((S)-5-Allyloxycarbonylamino-2-{(5S,10S)-10-[(S)-1-azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-pentanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 39 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / dioxane / 3.5 h / Heating

2: LiOH / H₂O; tetrahydrofuran; methanol / 3.5 h / 0 - 20 °C

3: 70 percent / Jones reagent / acetone / 3.5 h / 0 - 20 °C

With lithium hydroxide; jones reagent; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetone; 3: Jones oxidation;

DOI:10.1016/j.tet.2005.03.061

Reference yield:

[1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester (854443-36-0) → [(S)-4-{(5S,10S)-10-[(S)-1-Azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-5-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-5-oxo-pentyl]-carbamic acid allyl ester (854443-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / dioxane / 3.5 h / Heating

2: LiOH / H₂O; tetrahydrofuran; methanol / 3.5 h / 0 - 20 °C

With lithium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1016/j.tet.2005.03.061

upstream raw materials:

[(1S,2S)-1-(2-{[(S)-4-Allyloxycarbonylamino-1-((S)-2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid

2,3,4,5,6-pentafluorophenol

Downstream raw materials:

Formic acid (S)-1-((S)-5-allyloxycarbonylamino-2-{(5S,10S)-10-[(S)-1-azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-pentanoyl)-pyrrolidin-2-ylmethyl ester

[(S)-4-{(5S,10S)-10-[(S)-1-Azido-2-(4-benzyloxy-phenyl)-ethyl]-5-isobutyl-3,6-dioxo-[1,4,7]oxadiazecan-7-yl}-5-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-5-oxo-pentyl]-carbamic acid allyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 854443-36-0 [1-(2-{[4-allyloxycarbonylamino-1-(2-formyloxymethyl-pyrrolidine-1-carbonyl)-butyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoyl]-amino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid pentafluorophenyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send