ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate

Base Information

Chemical Name:ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate
CAS No.:123016-54-6
Molecular Formula:C₁₅H₁₃F₄NO₃
Molecular Weight:331.267
Hs Code.:

Synonyms:

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Chemical Property of ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate

Chemical Property:

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Technology Process of ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate

There total 4 articles about ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32890-92-9
2,3,4,6-tetrafluorobenzoic acid

: 123016-54-6
ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / SOCl₂ / dimethylformamide / 5.5 h / 90 - 140 °C

2: 1.) NaOEt / 1.) toluene, Rt, 1 h, 2.) toluene, 1h

3: p-TsOH*H₂O / H₂O / 3 h / Heating

4: 1.) Ac₂O / 1.) from 130 to 140 deg C, 2 h, 2.) EtOH, RT, overnight

With thionyl chloride; sodium ethanolate; acetic anhydride; toluene-4-sulfonic acid; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.2123

Reference yield:

: 123016-51-3
2,3,4,6-tetrafluorobenzoyl chloride

: 123016-54-6
ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOEt / 1.) toluene, Rt, 1 h, 2.) toluene, 1h

2: p-TsOH*H₂O / H₂O / 3 h / Heating

3: 1.) Ac₂O / 1.) from 130 to 140 deg C, 2 h, 2.) EtOH, RT, overnight

With sodium ethanolate; acetic anhydride; toluene-4-sulfonic acid; In water;
DOI:10.1248/cpb.43.2123

Reference yield:

: 133434-01-2
diethyl 2,3,4,6-tetrafluorobenzoylmalonate

: 123016-54-6
ethyl 2-(2,3,4,6-tetrafluorobenzoyl)-3-cyclopropylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH*H₂O / H₂O / 3 h / Heating

2: 1.) Ac₂O / 1.) from 130 to 140 deg C, 2 h, 2.) EtOH, RT, overnight

With acetic anhydride; toluene-4-sulfonic acid; In water;
DOI:10.1248/cpb.43.2123