[2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride

Base Information

• Chemical Name: [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride
• CAS No.: 891846-28-9
• Molecular Formula: C₁₆H₈BrCl₂NO₂
• Molecular Weight: 397.055
• Mol file: 891846-28-9.mol

Synonyms:

Chemical Property of [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride

There total 3 articles about [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromoacetophenone 4-chlorophenylhydrazone → [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride (891846-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / polyphosphoric acid / 0.5 h / 110 °C

2: diethyl ether / 4 h / Heating

With PPA; In diethyl ether; 1: Fischer indole synthesis;

DOI:10.1016/j.bmc.2006.01.039

Reference yield:

para-bromoacetophenone (99-90-1) → [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride (891846-28-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / glacial acetic acid / ethanol / Heating

2: 69 percent / polyphosphoric acid / 0.5 h / 110 °C

3: diethyl ether / 4 h / Heating

With PPA; acetic acid; In diethyl ether; ethanol; 2: Fischer indole synthesis;

DOI:10.1016/j.bmc.2006.01.039

Reference yield:

2-(4-bromophenyl)-5-chloro-1H-indole (891846-25-6) + oxalyl dichloride (79-37-8) → [2-(4-bromophenyl)-5-chloroindol-3-yl]glyoxylyl chloride (891846-28-9)

Guidance literature:

In diethyl ether; for 4h; Heating;

DOI:10.1016/j.bmc.2006.01.039

upstream raw materials:

2-(4-bromophenyl)-5-chloro-1H-indole

oxalyl dichloride

para-bromoacetophenone