4-Bromo-2,6-diethyl-pyridine

Base Information

• Chemical Name: 4-Bromo-2,6-diethyl-pyridine
• CAS No.: 877133-54-5
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Hs Code.: 2933399090
• Mol file: 877133-54-5.mol

Synonyms:4-Bromo-2,6-diethylpyridine;

Chemical Property of 4-Bromo-2,6-diethyl-pyridine

Chemical Property:

• Vapor Pressure: 0.0512mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 243 °C at 760 mmHg
• Flash Point: 100.8 °C
• PSA: 12.89000
• Density: 1.301g/cm³
• LogP: 2.96890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2,6-diethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2,6-diethylpyridine is a useful reactant for the synthesis of PF-?00868554 (I)?, an HCV polymerase inhibitor.

Technology Process of 4-Bromo-2,6-diethyl-pyridine

There total 3 articles about 4-Bromo-2,6-diethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,6-diethylpyridin-4-ol (1115035-61-4) → 4-bromo-2,6-diethyl-pyridine (877133-54-5)

Guidance literature:

With phosphorus(V) oxybromide; In N,N-dimethyl-formamide; at 120 ℃;

DOI:10.1055/s-0029-1219352

Reference yield: 72.0%

4-bromo-2,6-diethyIpyridine 1-oxide (1035267-63-0) → 4-bromo-2,6-diethyl-pyridine (877133-54-5)

Guidance literature:

4-bromo-2,6-diethyIpyridine 1-oxide; With phosphorus tribromide; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; In dichloromethane; water;

Reference yield: 0.8%

acetonedicarboxylic acid (542-05-2) + propionic acid anhydride (123-62-6) → 4-bromo-2,6-diethyl-pyridine (877133-54-5)

Guidance literature:

acetonedicarboxylic acid; propionic acid anhydride; With sulfuric acid; at 100 ℃;

With sodium hydrogencarbonate; In water; at 100 ℃; Further stages;

DOI:10.1021/acs.jmedchem.8b00387

upstream raw materials:

4-bromo-2,6-diethyIpyridine 1-oxide

2,6-diethylpyridin-4-ol

acetonedicarboxylic acid

propionic acid anhydride

Downstream raw materials:

C₂₆H₃₃NO₃

C₁₇H₂₃NO

2,6-Diethyl-4-cyanopyridin

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