6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

Base Information

Chemical Name:6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one
CAS No.:1242157-74-9
Molecular Formula:C₃₆H₄₀FN₇O₃
Molecular Weight:637.757
Hs Code.:

6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

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Chemical Property of 6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

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Technology Process of 6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

There total 6 articles about 6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242156-61-1
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

: 1293344-24-7
3-{[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino}-1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one

: 1242157-74-9
6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

Guidance literature:: With potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 88 ℃;
DOI:10.1016/j.bmcl.2014.11.030

Reference yield:

: 1123172-37-1
3-tert-butyl-5-fluoro-benzaldehyde

: 1242157-74-9
6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / 1 h / 20 °C

2.1: sec.-butyllithium / tetrahydrofuran / -70 - 10 °C

2.2: -70 - -10 °C

3.1: hydrazine hydrate; acetic acid / ethanol / 80 °C

4.1: caesium carbonate / 4 h / 60 °C

5.1: sodium tetrahydroborate / isopropyl alcohol; dichloromethane / 0.5 h / 4 °C

6.1: potassium carbonate; tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane; water / 88 °C

With sodium tetrahydroborate; hydrazine hydrate; sec.-butyllithium; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol; 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2014.11.030

Reference yield:

: 1123172-38-2
1-bromo-3-(tert-butyl)-5-fluorobenzene

: 1242157-74-9
6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; isopropylmagnesium chloride / tetrahydrofuran / -10 °C

2.1: toluene-4-sulfonic acid / 1 h / 20 °C

3.1: sec.-butyllithium / tetrahydrofuran / -70 - 10 °C

3.2: -70 - -10 °C

4.1: hydrazine hydrate; acetic acid / ethanol / 80 °C

5.1: caesium carbonate / 4 h / 60 °C

6.1: sodium tetrahydroborate / isopropyl alcohol; dichloromethane / 0.5 h / 4 °C

7.1: potassium carbonate; tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane; water / 88 °C

With sodium tetrahydroborate; n-butyllithium; hydrazine hydrate; sec.-butyllithium; isopropylmagnesium chloride; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol; 7.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2014.11.030