(6-Trifluoromethyl-pyridin-2-yl)-methanol

Base Information

• Chemical Name: (6-Trifluoromethyl-pyridin-2-yl)-methanol
• CAS No.: 131747-53-0
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.1238
• Hs Code.: 2933399090
• Mol file: 131747-53-0.mol

Synonyms:(6-Trifluoromethyl-pyridin-2-yl)-methanol;6-(Trifluoromethyl)-2-pyridinemethanol

Chemical Property of (6-Trifluoromethyl-pyridin-2-yl)-methanol

Chemical Property:

• Refractive Index: 1.462
• Boiling Point: 191.1 °C at 760 mmHg
• PKA: 12.99±0.10(Predicted)
• Flash Point: 69.4 °C
• PSA: 33.12000
• Density: 1.362 g/cm³
• LogP: 1.59270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(6-(Trifluoromethyl)pyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-Trifluoromethyl-pyridin-2-yl)-methanol

There total 8 articles about (6-Trifluoromethyl-pyridin-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester (155377-05-2) → [6-(trifluoromethyl)pyridin-2-yl]methanol (131747-53-0)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at 20 ℃;

Reference yield:

6-(trifluoromethyl)pyridine-2-carboxylic acid (131747-42-7) → [6-(trifluoromethyl)pyridin-2-yl]methanol (131747-53-0)

Guidance literature:

With lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min;

DOI:10.1248/cpb.38.2446

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-bromo-6-(trifluoromethyl)pyridine (189278-27-1) → [6-(trifluoromethyl)pyridin-2-yl]methanol (131747-53-0)

Guidance literature:

2-bromo-6-(trifluoromethyl)pyridine; With n-butyllithium; In toluene; at -78 ℃;

N,N-dimethyl-formamide; In toluene; at -78 ℃;

With methanol; sodium tetrahydroborate; In toluene; at -78 - 20 ℃;

upstream raw materials:

6-(trifluoromethyl)pyridine-2-carboxylic acid

2-Amino-6-methylpyridine

2-bromo-6-methylpyridine

2-methyl-6-(trifluoromethyl)pyridine

Downstream raw materials:

6-(trifluoromethyl)-2-pyridinecarboxaldehyde

2-(bromomethyl)-6-(trifluoromethyl)pyridine

2-(chloromethyl)-6-(trifluoromethyl)pyridine

2,6-dimethyl-4-(6-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Refernces

• 1、 -. "NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)". . . Retrieved 2020/11/12.
• 2、 Mormino, Michael G.,Fier, Patrick S.,Hartwig, John F.. "Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF". . p. 1744 - 1747. Retrieved 2014/04/17.