1-[(2,6-Difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

Base Information

Chemical Name:1-[(2,6-Difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid
CAS No.:304859-20-9
Molecular Formula:C₁₂H₁₁F₂NO₃
Molecular Weight:255.221
Hs Code.:
European Community (EC) Number:842-497-4

Synonyms:304859-20-9;1-[(2,6-difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid;1-(2,6-Difluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid;1-(2,6-difluorobenzyl)-5-oxo-3-pyrrolidinecarboxylic acid;SCHEMBL7461058;AKOS005207624;EN300-238439;F2147-0032;1-(2,6-Difluorobenzyl)-5-oxopyrrolidine-3-carboxylicacid

Suppliers and Price of 1-[(2,6-Difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(Tosylcarbamoyl)glycine AldrichCPR
50mg
$ 83.50

AK Scientific
1-(2,6-Difluorobenzyl)-5-oxopyrrolidine-3-carboxylicacid
250mg
$ 391.00

Total 2 raw suppliers

Chemical Property of 1-[(2,6-Difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:255.07069954
Heavy Atom Count:18
Complexity:340

Purity/Quality:

98%,99%, ^*data from raw suppliers

(Tosylcarbamoyl)glycine AldrichCPR ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(CN(C1=O)CC2=C(C=CC=C2F)F)C(=O)O

Technology Process of 1-[(2,6-Difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

There total 1 articles about 1-[(2,6-Difluorophenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 69385-30-4
2,6-difluorobenzylamine

: 304859-20-9
1-(2,6-difluorobenzyl)-5-oxo-3-pyrrolidinecarboxylic acid

Guidance literature:

Reference yield: 76.0%

: 304859-20-9
1-(2,6-difluorobenzyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 79-37-8
oxalyl dichloride

: N-[3-(4-Benzyl-1-piperidinyl)propyl]aniline dihydrochloride

: N-[3-(4-benzyl-1-piperidinyl)propyl]-1-(2,6-difluorophenyl)-5-oxo-N-phenyl-3-pyrrolidinecarboxamide

Guidance literature:: 1-(2,6-difluorobenzyl)-5-oxo-3-pyrrolidinecarboxylic acid; oxalyl dichloride;

N-[3-(4-Benzyl-1-piperidinyl)propyl]aniline dihydrochloride; With triethylamine;