(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate
CAS No.:16217-15-5
Molecular Formula:C14H15NO5
Molecular Weight:277.277
Hs Code.:
DSSTox Substance ID:DTXSID50469163
Wikidata:Q82296759
Mol file:16217-15-5.mol

Synonyms:16217-15-5;(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate;1-O-benzyl 2-O-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate;(s)-L-benzyl-2-methyl 4-oxopyrrolidine-1,2-dicarboxylate;1-benzyl 2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate;Methyl (S)-1-Cbz-4-oxo-2-pyrrolidinecarboxylate;MFCD09608116;(2S)-4-Oxo-1,2-pyrrolidinedicarboxylic Acid 1-Benzyl 2-Methyl Ester;1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 2-methyl 1-(phenylmethyl) ester, (2S)-;XRFKZAWVKVORNI-LBPRGKRZSA-N;SCHEMBL204264;(S)-L-benzyl2-methyl4-oxopyrrolidine-1,2-dicarboxyl;(S)-1-Benzyl2-methyl4-oxopyrrolidine-1,2-dicarboxylate;(S)-L-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxyl;(s)-L-benzyl-2-methyl4-oxopyrrolidine-1,2-dicarboxylate;DTXSID50469163;AMY36452;AKOS015995268;AKOS016008678;HY-W063269;s10567;AS-73724;BP-22760;PD197233;A3605;CS-0055123;EN300-7421474;(S)-1-benzyloxycarbonyl-4-oxoproline methyl ester;(S)-CBZ 1-methyl-4-oxopyrrolidine-2-carboxylate;1-benzyloxycarbonyl-4-keto-(S)-proline methyl ester;J-502492;Methyl (S)-1-CBZ-4-oxo-2-pyrrolidine carboxylate;(2S)-3-benzyl-2-methyl-4-oxopyrrolidine-1,2-dicarboxylate;1-benzyl 2-methyl (S)-4-oxopyrrolidine-1,2-dicarboxylate;O1-Benzyl O2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate;2-methyl 1-(phenylmethyl) (2S)-4-oxo-1,2-pyrrolidinedicarboxylate

Suppliers and Price of (S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-4-Oxo-1,2-pyrrolidinedicarboxylicAcid1-Benzyl2-MethylEster
25mg
$ 165.00

SynQuest Laboratories
1-Benzyl 2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate
100 mg
$ 504.00

Medical Isotopes, Inc.
(2S)-4-Oxo-1,2-pyrrolidinedicarboxylicAcid1-Benzyl2-MethylEster
25 mg
$ 650.00

Matrix Scientific
(S)-L-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxyl 98%
5g
$ 820.00

Matrix Scientific
(S)-L-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxyl 98%
1g
$ 275.00

Crysdot
(S)-1-Benzyl2-methyl4-oxopyrrolidine-1,2-dicarboxylate 95%
250mg
$ 87.00

Crysdot
(S)-1-Benzyl2-methyl4-oxopyrrolidine-1,2-dicarboxylate 95%
1g
$ 218.00

Crysdot
(S)-1-Benzyl2-methyl4-oxopyrrolidine-1,2-dicarboxylate 95%
5g
$ 653.00

Chemenu
1-benzyl2-methyl(S)-4-oxopyrrolidine-1,2-dicarboxylate 95%
5g
$ 617.00

Chemenu
1-benzyl2-methyl(S)-4-oxopyrrolidine-1,2-dicarboxylate 95%
1g
$ 206.00

Total 32 raw suppliers

Chemical Property of (S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.559
Boiling Point:422.051 °C at 760 mmHg
PKA:-3.91±0.40(Predicted)
Flash Point:209.049 °C
PSA：72.91000
Density:1.307g/cm³
LogP:1.07750
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform, Dichloromethane, Dimethylsulfoxide, Ethyl Acetate
XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:277.09502258
Heavy Atom Count:20
Complexity:389

Purity/Quality:

99% ^*data from raw suppliers

(2S)-4-Oxo-1,2-pyrrolidinedicarboxylicAcid1-Benzyl2-MethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CC(=O)CN1C(=O)OCC2=CC=CC=C2
Isomeric SMILES:COC(=O)[C@@H]1CC(=O)CN1C(=O)OCC2=CC=CC=C2
Uses (S)-1-Benzyl 2-Methyl 4-Oxopyrrolidine-1,2-Dicarboxylate is used in the preparation of dipeptidyl peptidase IV inhibitors and (hydroxy)(carbamoyl)pyrimidinones as potent and orally bioavailable HIV integrase inhibitors.

Technology Process of (S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

There total 13 articles about (S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%