1-BOC-3-METHANESULFONYLOXYMETHYL-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-3-METHANESULFONYLOXYMETHYL-PIPERIDINE
• CAS No.: 162166-99-6
• Molecular Formula: C12H23NO5S
• Molecular Weight: 293.384
• Hs Code.: 29333990
• Mol file: 162166-99-6.mol

Synonyms:3-[(Methanesulfonyloxy)methyl]piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 1-BOC-3-METHANESULFONYLOXYMETHYL-PIPERIDINE

Chemical Property:

• Boiling Point: 418.78 °C at 760 mmHg
• PKA: -2.08±0.40(Predicted)
• Flash Point: 207.071 °C
• PSA: 81.29000
• Density: 1.175 g/cm³
• LogP: 2.62840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-Methanesulfonyloxymethyl-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-3-METHANESULFONYLOXYMETHYL-PIPERIDINE

There total 7 articles about 1-BOC-3-METHANESULFONYLOXYMETHYL-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + (±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (116574-71-1) → 3-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester (162166-99-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

(±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (116574-71-1) → 3-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester (162166-99-6)

Guidance literature:

With trifluoromethylsulfonic anhydride; In 1,1-dichloroethane;

Reference yield:

3-(hydroxymethy)piperidine (4606-65-9) → 3-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester (162166-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₃N / dioxane / 2 h

2: Et₃N / CH₂Cl₂

With triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/S0960-894X(98)00290-X

upstream raw materials:

methanesulfonyl chloride

(±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate

3-(hydroxymethy)piperidine

di-tert-butyl dicarbonate

Downstream raw materials:

4-(benzyloxy)-3-bromo-1-(piperidin-3-ylmethyl)pyridin-2(1H)-one hydrochloride

t-butyl 3-(methoxymethyl)piperidine-1-carboxylate

tert-butyl-3-((6-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)piperidine-1-carboxylate

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