Technology Process of (E)-(3-(but-1-en-3-ynyl)-2-chlorophenoxy)(tert-butyl)dimethylsilane
There total 6 articles about (E)-(3-(but-1-en-3-ynyl)-2-chlorophenoxy)(tert-butyl)dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diazomethyl-trimethyl-silane;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
C15H21ClO2Si;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 4h;
Reflux;
Inert atmosphere;
DOI:10.1039/c4ob00250d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.25 h / -78 - 0 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
5.2: 4 h / -78 °C / Reflux; Inert atmosphere
With
1H-imidazole; n-butyllithium; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination / 5.1: |Colvin Alkyne Synthesis / 5.2: |Colvin Alkyne Synthesis;
DOI:10.1039/c4ob00250d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.25 h / -78 - 0 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
5.2: 4 h / -78 °C / Reflux; Inert atmosphere
With
1H-imidazole; n-butyllithium; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination / 5.1: |Colvin Alkyne Synthesis / 5.2: |Colvin Alkyne Synthesis;
DOI:10.1039/c4ob00250d
