Benzyl 2-aminoethyl(methyl)carbamate

Base Information

• Chemical Name: Benzyl 2-aminoethyl(methyl)carbamate
• CAS No.: 19023-94-0
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.26
• DSSTox Substance ID: DTXSID10597052
• Wikidata: Q72442039
• Mol file: 19023-94-0.mol

Synonyms:19023-94-0;BENZYL 2-AMINOETHYL(METHYL)CARBAMATE;benzyl N-(2-aminoethyl)-N-methylcarbamate;N-Cbz-N-Methylethylenediamine;Carbamic acid, N-(2-aminoethyl)-N-methyl-, phenylmethyl ester;Benzyl (2-aminoethyl)methylcarbamate;SCHEMBL1329140;DTXSID10597052;BEIBNZUDHJCOKR-UHFFFAOYSA-N;DIETHOXYPHOSPHINYLISOCYANATE;BENZYL2-AMINOETHYL(METHYL)CARBAMATE;DB-065715;(2-amino-ethyl)-methyl-carbamic acid benzyl ester;A813400

Chemical Property of Benzyl 2-aminoethyl(methyl)carbamate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 327.6 °C at 760 mmHg
• Flash Point: 151.9 °C
• Density: 1.118 g/cm³
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 208.121177757
• Heavy Atom Count: 15
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

Benzyl2-aminoethyl(methyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(CCN)C(=O)OCC1=CC=CC=C1

Technology Process of Benzyl 2-aminoethyl(methyl)carbamate

There total 7 articles about Benzyl 2-aminoethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

mono-tert-butyl malonate (40052-13-9) + 2-Amino-5-({amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-pentanoic acid ((R)-1-methyl-2-phenyl-ethyl)-amide → (2-aminoethyl)-methylcarbamic acid,benzyl ester (19023-94-0) + N-[4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-4-sulfonylimino]-methyl}-amino-1-((R)-1-methyl-2-phenyl-ethylcarbamoyl)-butyl]-malonamic acid tert-butyl ester

Guidance literature:

With DIEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide;

Reference yield: 89.0%

methyl-[2-(2,2,2-trifluoro-acetylamino)-ethyl]carbamic acid benzyl ester (1221593-52-7) → (2-aminoethyl)-methylcarbamic acid,benzyl ester (19023-94-0)

Guidance literature:

With lithium hydroxide; In methanol; water; at 20 ℃; for 3h;

Reference yield:

{[(S)-2-tert-Butoxycarbonylamino-3-(2-nitro-benzenesulfonylamino)-propionyl]-methyl-amino}-acetic acid ethyl ester → (2-aminoethyl)-methylcarbamic acid,benzyl ester (19023-94-0)

Guidance literature:

With hydrogenchloride; LiOH; In methanol; water;

upstream raw materials:

N-Benzyliden-N'-methylethylendiamin

benzyl chloroformate

N-methyl-ethane-1,2-diamine

N-(benzyloxycarbonyl)succinimide

Downstream raw materials:

C₃₂H₅₂N₆O₉

[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-dicarbamic acid tert-butyl ester

{(S)-4-({amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethyl carbamoyl]-butyl}-carbamic acid tert-butyl ester

{(S)-5-acetylamino-5-[2-(benzyloxycarbonyl-methyl-amino)-ethyl carbamoyl]-pentyl}-carbamic acid isopropyl ester