6-fluoro-2,3-diMethoxybenzoic acid

Base Information

• Chemical Name: 6-fluoro-2,3-diMethoxybenzoic acid
• CAS No.: 265670-72-2
• Molecular Formula: C9H9 F O4
• Molecular Weight: 200.166
• Mol file: 265670-72-2.mol

Synonyms:5,6-Dimethoxy-2-fluorobenzoicacid; 6-Fluoro-2,3-dimethoxybenzoic acid

Chemical Property of 6-fluoro-2,3-diMethoxybenzoic acid

Chemical Property:

• Boiling Point: 297.3±35.0 °C(Predicted)
• PKA: 3.04±0.10(Predicted)
• PSA: 55.76000
• Density: 1.298±0.06 g/cm3(Predicted)
• LogP: 1.54110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-fluoro-2,3-dimethoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-fluoro-2,3-diMethoxybenzoic acid

There total 1 articles about 6-fluoro-2,3-diMethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

carbon dioxide (124-38-9,18923-20-1) + 4-fluoroveratrole (398-62-9) → 6-fluoro-2,3-dimethoxybenzoic acid (265670-72-2)

Guidance literature:

4-fluoroveratrole; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -60 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; hexane; at -60 ℃; for 0.5h;

DOI:10.1021/jm030317k

Reference yield: 100.0%

6-fluoro-2,3-dimethoxybenzoic acid (265670-72-2) → 6-fluoro-2,3-dihydroxybenzoic acid (492444-05-0)

Guidance literature:

With hydrogen bromide; acetic acid; In water; for 1h; Heating;

DOI:10.1021/jm030317k

Reference yield: 85.0%

4-amino-6-chloro-N-methylpyridine-3-carboxamide + 6-fluoro-2,3-dimethoxybenzoic acid (265670-72-2) → 6-chloro-4-[(6-fluoro-2,3-dimethoxybenzoyl)amino]-N-methylpyridine-3-carboxamide

Guidance literature:

6-fluoro-2,3-dimethoxybenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-amino-6-chloro-N-methylpyridine-3-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

upstream raw materials:

carbon dioxide

4-fluoroveratrole

Downstream raw materials:

6-fluoro-2,3-dimethoxy-benzoyl chloride

6-fluoro-2,3-dihydroxybenzoic acid

5-fluoro-1,3-benzodioxol-4-amine

methyl 6-fluoro-2,3-dihydroxybenzoate