Methyl 6-fluoro-2,3-dihydroxybenzoate

Base Information

Chemical Name:Methyl 6-fluoro-2,3-dihydroxybenzoate
CAS No.:492444-06-1
Molecular Formula:C8H7FO4
Molecular Weight:186.14
Hs Code.:
DSSTox Substance ID:DTXSID601221534
Mol file:492444-06-1.mol

Synonyms:methyl 6-fluoro-2,3-dihydroxybenzoate;492444-06-1;Benzoic acid, 6-fluoro-2,3-dihydroxy-, methyl ester;SCHEMBL4497012;DTXSID601221534

Suppliers and Price of Methyl 6-fluoro-2,3-dihydroxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 6-fluoro-2,3-dihydroxybenzoate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:186.03283686
Heavy Atom Count:13
Complexity:197

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(C=CC(=C1O)O)F

Technology Process of Methyl 6-fluoro-2,3-dihydroxybenzoate

There total 3 articles about Methyl 6-fluoro-2,3-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 67-56-1
methanol

: 492444-05-0
6-fluoro-2,3-dihydroxybenzoic acid

: 492444-06-1
methyl 6-fluoro-2,3-dihydroxybenzoate

Guidance literature:: With thionyl chloride; at 70 ℃; for 18h;
DOI:10.1021/jm030317k

Reference yield:

: 398-62-9
4-fluoroveratrole

: 492444-06-1
methyl 6-fluoro-2,3-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -60 °C

1.2: 64 percent / tetrahydrofuran; hexane / 0.5 h / -60 °C

2.1: 100 percent / HBr; AcOH / H₂O / 1 h / Heating

3.1: 60 percent / SOCl₂ / 18 h / 70 °C

With thionyl chloride; hydrogen bromide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; water;
DOI:10.1021/jm030317k

Reference yield:

: 265670-72-2
6-fluoro-2,3-dimethoxybenzoic acid

: 492444-06-1
methyl 6-fluoro-2,3-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / HBr; AcOH / H₂O / 1 h / Heating

2: 60 percent / SOCl₂ / 18 h / 70 °C

With thionyl chloride; hydrogen bromide; acetic acid; In water;
DOI:10.1021/jm030317k