Technology Process of 3-([S]-α-ethylbenzyl)-4-hydroxy-6-([R]-α-ethylphenethyl)-2H-pyran-2-one
There total 27 articles about 3-([S]-α-ethylbenzyl)-4-hydroxy-6-([R]-α-ethylphenethyl)-2H-pyran-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diethyl ether
2.1: Acidic conditions
3.1: methanol
4.1: lithium diisopropyl amide
5.1: toluene / Heating / reflux
5.2: Acidic conditions
With
lithium diisopropyl amide;
In
methanol; diethyl ether; toluene;
- Guidance literature:
-
Multi-step reaction with 10 steps
2.1: hydrogen / palladium on carbon
3.1: Alkaline conditions
4.1: diethyl chlorophosphate; triethylamine
5.1: phosphoric acid / 150 - 160 °C
6.1: oxalyl dichloride / dichloromethane / 2 h / Heating / reflux
7.1: triethylamine / toluene / 2.5 h / Heating / reflux
8.1: sodium carbonate / methanol; water / 20 °C
9.1: lithium diisopropyl amide
10.1: toluene / Heating / reflux
10.2: Acidic conditions
With
oxalyl dichloride; phosphoric acid; hydrogen; sodium carbonate; diethyl chlorophosphate; triethylamine; lithium diisopropyl amide;
palladium on carbon;
In
methanol; dichloromethane; water; toluene;
1.1: Claisen Rearrangement;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: cooper catalyst / tetrahydrofuran
3.1: methanol
4.1: lithium diisopropyl amide
5.1: toluene / Heating / reflux
5.2: Acidic conditions
With
lithium diisopropyl amide;
cooper catalyst;
In
tetrahydrofuran; methanol; toluene;
